Asparagine-linked protein glycosylation is a prevalent protein modification reaction in
eukaryotic systems. This process involves the co-translational transfer of a pre-assembled …

… Epoxides (Figure 2c), with structures similar to the broad-spectrum cysteine protease inhibitor
E-64, can target cysteine proteases [31]. Epoxides are very mild electrophiles, and in the …

… We thank members of the Weerapana Lab for comments and critical reading of the … Pace
and Eranthie Weerapana contributed to reviewing literature and writing of the manuscript. …

Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is
tuned to perform diverse biochemical functions. The absence of a consensus sequence that …

We have developed a general synthetic route to encapsulate small molecules in monodisperse
zeolitic imid-azolate framework-8 (ZIF-8) nanospheres for drug delivery. Electron …

Endocannabinoids are lipid signaling molecules that regulate a wide range of mammalian
behaviors, including pain, inflammation, and cognitive/emotional state. The endocannabinoid …

This article presents several covalent inhibitors, including examples of successful drugs, as
well as highly selective, irreversible inhibitors of emerging therapeutic targets, such as fatty …

Activity-based protein profiling (ABPP) utilizes active site-directed chemical probes to monitor
the functional state of enzymes directly in native biological systems. Identification of the …

Redox control of protein function involves oxidation and reduction of amino acid residues, but
the mechanisms and regulators involved are insufficiently understood. Here, we report that …

Cells produce electrophilic products with the potential to modify and affect the function of
proteins. Chemoproteomic methods have provided a means to qualitatively inventory proteins …