Cell size is fundamental to cell physiology because it sets the scale of intracellular geometry,
organelles, and biosynthetic processes. In animal cells, size homeostasis is controlled …

The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive
cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, …

Cell size is tightly controlled in healthy tissues, but it is unclear how deviations in cell size
affect cell physiology. To address this, we measured how the cell's proteome changes with …

Blebs and F-actin–driven pseudopods are alternative ways of extending the leading edge of
migrating cells. We show that Dictyostelium cells switch from using predominantly …

… Zatulovskiy et al. propose that human cells sense the concentration of the retinoblastoma
family protein Rb. Rb itself acts on transcription factors to inhibit progression through the cell …

… expression of downstream cyclins E and A that activate Cdk2 to complete Rb inactivation
and initiate E2F-dependent transcriptional activation. The E2F-Rb-cyclin E circuit is a positive …

Two motors can drive extension of the leading edge of motile cells: actin polymerization and
myosin-driven contraction of the cortex, producing fluid pressure and the formation of blebs. …

Increasing cell size drives changes to the proteome, which affects cell physiology. As cell size
increases, some proteins become more concentrated while others are diluted. As a result, …

Every type of cell in an animal maintains a specific size, which likely contributes to its ability
to perform its physiological functions. While some cell size control mechanisms are …

Cell size is important for cell physiology because it sets the geometric scale of organelles and
biosynthesis. A number of methods exist to measure different aspects of cell size, but each …