The hexanucleotide G 4 C 2 repeat expansion in the first intron of the C9ORF72 gene accounts
for the majority of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) …

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a rare neurodegenerative disorder
caused by a 55–200 CGG repeat expansion in the 5′ untranslated region of the Fragile X …

The hexanucleotide (G 4 C 2 )-repeat expansion in the C9ORF72 gene is the most common
pathogenic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). …

… Esmay C van der Toorn , Esmay C van der Toorn … The authors thank the Netherlands
Brain Bank for providing tissue and Irene van Dijken for her input on the immunofluorescence …

Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability
and autism spectrum disorders. Mostly, FXS is caused by transcriptional silencing of the …

… van der Toorn … van der Toorn … For the latter, so-called enoate reductases [EC 1.3.1.X] (or
old yellow enzymes, OYEs)6 have recently experienced a renewed interest as catalysts for the …

Cigarette smoke–induced apoptosis and necrosis contribute to the pathogenesis of chronic
obstructive pulmonary disease. The induction of heme oxygenase-1 provides cytoprotection …

… EC 50 values of a variety of aldehydes that are able to deplete GSH showed that acrolein
was by far the most effective one to bind to GSH followed by formaldehyde and …

… Moreover, the “critical field” is given by Ec ∼ vth/μ0, while in the case of velocity saturation
we have Ec ∼ vsat/μ0. Unfortunately, the thermal velocity vth at room temperature has almost …

Increased lung cell apoptosis and necrosis occur in patients with chronic obstructive pulmonary
disease (COPD). Mitochondria are crucially involved in the regulation of these cell death …