During mouse embryonic development a mass of pluripotent epiblast tissue is transformed
during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and …

Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues, …

… The fact that only a small number of genes were bivalently modified in the HFSCs suggests
that this state is less important in adult somatic stem cells than in ES cells, where it is critical …

… pressure points followed a linear end-systolic pressure-volume relation (ESPVR) (R 2 =
0.98) with a slope of 0.28 mmH 2 O•mm −3 representing the end-systolic elastance (E es ), a …

… Despite the similarity to ES cells, our studies also uncovered clear differences between
Polycomb regulation of ES and epidermal stem cells. In ES cells, the Polycomb complex has …

… stem cells located in the basal layer of the epidermis (Bardot et al., 2013; Morrison et al., …
The quantification of Merkel cells per mm of skin was performed as described in Bardot et al…

Transcriptional and epigenetic profiling of single-cells has advanced our knowledge of the
molecular bases of gastrulation and early organogenesis. However, current approaches rely …

During development multiple progenitor populations contribute to the formation of the four-chambered
heart and its diverse lineages. However, the underlying mechanisms that result in …

Chromatin regulatory complexes are well known regulators of stem cell fate; however, the
mechanisms regulating their activity are not well understood. In this issue of Cell Stem Cell, …

The adult mammalian heart is minimally regenerative after injury, whereas neonatal hearts
fully recover even after major damage. New work from the Red-Horse and Woo labs (Das et al…