Early life stress, such as childhood abuse, neglect and loss, is a well established major risk
factor for developing depressive disorders later in life. We here summarize and discuss …

… Binder has received grant support from Pfizer Pharmaceuticals, GSK and NARSAD. … Binder
receives grant support from NIMH and the Doris Duke charitable foundation. Dr. Binder is co-…

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a
collaborative network of researchers working together on a range of large-scale studies that …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Context In addition to trauma exposure, other factors contribute to risk for development of
posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors are …

Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …

The stress hormone–regulating hypothalamic-pituitary-adrenal (HPA) axis has been
implicated in the causality 1 as well as the treatment of depression 2 . To investigate a possible …

Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…

… Binder c f … Research Council starting Grant (Grant #281338) G × E molmech, FP7 framework
program to EB. … R Yehuda, J Schmeidler, M Wainberg, K Binder-Brynes, T Duvdevani …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to broadly regulate the
cellular stress response. In contrast, it is unclear if the PACAP–PAC1 receptor pathway has …