User profiles for EN Larschan
Erica LarschanProfessor of Biology, Brown University Verified email at brown.edu Cited by 4293 |
[HTML][HTML] Comparative analysis of metazoan chromatin organization
…, CV Kotwaliwale, N Kumar, SA Langley, EN Larschan… - Nature, 2014 - nature.com
Genome function is dynamically regulated in part by chromatin, which consists of the histones,
non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis …
non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis …
[HTML][HTML] Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types
Background For many genes, RNA polymerase II stably pauses before transitioning to
productive elongation. Although polymerase II pausing has been shown to be a mechanism for …
productive elongation. Although polymerase II pausing has been shown to be a mechanism for …
Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP
…, WF Marzluff, RJ Duronio, EN Larschan - Genes & …, 2017 - genesdev.cshlp.org
The conserved histone locus body (HLB) assembles prior to zygotic gene activation early
during development and concentrates factors into a nuclear domain of coordinated histone …
during development and concentrates factors into a nuclear domain of coordinated histone …
Wisdom from the fly
LE Rieder, EN Larschan - Trends in Genetics, 2014 - cell.com
Arguably, almost all research in Drosophila can be considered basic research, yet many of
the most essential and fundamental concepts of human genetics were first decoded in the fly. …
the most essential and fundamental concepts of human genetics were first decoded in the fly. …
The essential Drosophila CLAMP protein differentially regulates non-coding roX RNAs in male and females
Heterogametic species require chromosome-wide gene regulation to compensate for
differences in sex chromosome gene dosage. In Drosophila melanogaster, transcriptional output …
differences in sex chromosome gene dosage. In Drosophila melanogaster, transcriptional output …
[PDF][PDF] Targeting of the dosage-compensated male X-chromosome during early Drosophila development
Dosage compensation, which corrects for the imbalance in X-linked gene expression
between XX females and XY males, represents a model for how genes are targeted for …
between XX females and XY males, represents a model for how genes are targeted for …
The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males
…, A Bonchuk, V Mogila, EN Larschan… - …, 2019 - journals.biologists.com
The binding of the Drosophila male-specific lethal dosage compensation complex (DCC)
exclusively to the male X chromosome provides an excellent model system to understand …
exclusively to the male X chromosome provides an excellent model system to understand …
[HTML][HTML] The Drosophila CLAMP protein associates with diverse proteins on chromatin
JA Urban, JM Urban, G Kuzu, EN Larschan - PloS one, 2017 - journals.plos.org
Gaining new insights into gene regulation involves an in-depth understanding of protein-protein
interactions on chromatin. A powerful model for studying mechanisms of gene …
interactions on chromatin. A powerful model for studying mechanisms of gene …
[PDF][PDF] Dosage compensation: how to be compensated… or not?
J Duan, EN Larschan - Current Biology, 2019 - cell.com
Diverse dosage compensation mechanisms have evolved across species to equalize gene
expression between sexes and between the sex chromosomes and autosomes. New results …
expression between sexes and between the sex chromosomes and autosomes. New results …
The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster
… LX contributed to sample collection for RNA-seq experiments and immunohistochemistry,
EN contributed in size experiments and AMC contributed in RNA-seq data analysis. MAT …
EN contributed in size experiments and AMC contributed in RNA-seq data analysis. MAT …