User profiles for EN Larschan

Erica Larschan

Professor of Biology, Brown University
Verified email at brown.edu
Cited by 4293

[HTML][HTML] Comparative analysis of metazoan chromatin organization

…, CV Kotwaliwale, N Kumar, SA Langley, EN Larschan… - Nature, 2014 - nature.com
Genome function is dynamically regulated in part by chromatin, which consists of the histones,
non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis …

[HTML][HTML] Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types

DS Day, B Zhang, SM Stevens, F Ferrari, EN Larschan… - Genome biology, 2016 - Springer
Background For many genes, RNA polymerase II stably pauses before transitioning to
productive elongation. Although polymerase II pausing has been shown to be a mechanism for …

Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP

…, WF Marzluff, RJ Duronio, EN Larschan - Genes & …, 2017 - genesdev.cshlp.org
The conserved histone locus body (HLB) assembles prior to zygotic gene activation early
during development and concentrates factors into a nuclear domain of coordinated histone …

Wisdom from the fly

LE Rieder, EN Larschan - Trends in Genetics, 2014 - cell.com
Arguably, almost all research in Drosophila can be considered basic research, yet many of
the most essential and fundamental concepts of human genetics were first decoded in the fly. …

The essential Drosophila CLAMP protein differentially regulates non-coding roX RNAs in male and females

…, MM Soruco, LE Rieder, MA Tsiarli, EN Larschan - Chromosome …, 2017 - Springer
Heterogametic species require chromosome-wide gene regulation to compensate for
differences in sex chromosome gene dosage. In Drosophila melanogaster, transcriptional output …

[PDF][PDF] Targeting of the dosage-compensated male X-chromosome during early Drosophila development

LE Rieder, WT Jordan, EN Larschan - Cell reports, 2019 - cell.com
Dosage compensation, which corrects for the imbalance in X-linked gene expression
between XX females and XY males, represents a model for how genes are targeted for …

The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males

…, A Bonchuk, V Mogila, EN Larschan… - …, 2019 - journals.biologists.com
The binding of the Drosophila male-specific lethal dosage compensation complex (DCC)
exclusively to the male X chromosome provides an excellent model system to understand …

[HTML][HTML] The Drosophila CLAMP protein associates with diverse proteins on chromatin

JA Urban, JM Urban, G Kuzu, EN Larschan - PloS one, 2017 - journals.plos.org
Gaining new insights into gene regulation involves an in-depth understanding of protein-protein
interactions on chromatin. A powerful model for studying mechanisms of gene …

[PDF][PDF] Dosage compensation: how to be compensated… or not?

J Duan, EN Larschan - Current Biology, 2019 - cell.com
Diverse dosage compensation mechanisms have evolved across species to equalize gene
expression between sexes and between the sex chromosomes and autosomes. New results …

The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster

MA Tsiarli, AM Conard, L Xu, E Nguyen, EN Larschan - bioRxiv, 2020 - biorxiv.org
… LX contributed to sample collection for RNA-seq experiments and immunohistochemistry,
EN contributed in size experiments and AMC contributed in RNA-seq data analysis. MAT …