Molecular approaches to understanding the functional circuitry of the nervous system
promise new insights into the relationship between genes, brain and behaviour. The cellular …

The Cre/lox system is widely used in mice to achieve cell-type-specific gene expression.
However, a strong and universally responding system to express genes under Cre control is still …

Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources
to complement genomic sequence data and to correlate functional and genetic brain …

We present a high-quality genome sequence of a Neanderthal woman from Siberia. We
show that her parents were related at the level of half-siblings and that mating among close …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

The precise functional role of the hippocampus remains a topic of much debate. The dominant
view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial …

Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

The anatomical and functional architecture of the human brain is mainly determined by prenatal
transcriptional processes. We describe an anatomically comprehensive atlas of the mid-…

Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown etiology.
Recent studies employing exome- and genome-wide sequencing have identified nine high-…

Background Autism involves early brain overgrowth and dysfunction, which is most strongly
evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons …