Due to commonalities in pathophysiology, age-related macular degeneration (AMD) represents
a uniquely accessible model to investigate therapies for neurodegenerative diseases, …

There is increasing evidence of astrocyte dysfunction in the pathogenesis of Alzheimer’s
disease (AD). Animal studies supported by human post-mortem work have demonstrated two …

1 One Sentence Summary A novel topological machine learning approach applied to single-nucleus
RNA sequencing from human retinas with age-related macular degeneration …

Purpose: Reactive Müller glial cells in humans do not display the regenerative characteristics
of those in zebrafish. We performed the first single-nucleus RNA sequencing of retina from …

Age-related macular degeneration (AMD) is a degenerative disease of the retina with unknown
cellular drivers. To identify, characterize, and compare rare pathogenic clusters of cells, …

In an effort to computationally predict causal genetic networks and derive biological pathways
empirically, biomedical scientists have begun to design increasingly complicated single …

Persistent homology is a popular computational tool for detecting non-trivial topology of point
clouds, such as the presence of loops or voids. However, many real-world datasets with …