User profiles for Eddie Park
 | Eddie Joon ParkChildren's Hospital of Philadelphia Verified email at uci.edu Cited by 20215 |
[PDF][PDF] The expanding landscape of alternative splicing variation in human populations
Alternative splicing is a tightly regulated biological process by which the number of gene
products for any given gene can be greatly expanded. Genomic variants in splicing regulatory …
products for any given gene can be greatly expanded. Genomic variants in splicing regulatory …
[HTML][HTML] Landscape of transcription in human cells
Eukaryotic cells make many types of primary and processed RNAs that are found either in
specific subcellular compartments or throughout the cells. A complete catalogue of these …
specific subcellular compartments or throughout the cells. A complete catalogue of these …
RNA editing in the human ENCODE RNA-seq data
E Park, B Williams, BJ Wold, A Mortazavi - Genome research, 2012 - genome.cshlp.org
RNA-seq data can be mined for sequence differences relative to the reference genome to
identify both genomic SNPs and RNA editing events. We analyzed the long, polyA-selected, …
identify both genomic SNPs and RNA editing events. We analyzed the long, polyA-selected, …
The spreader flap in primary rhinoplasty
RP Gruber, E Park, J Newman… - Plastic and …, 2007 - journals.lww.com
Background: In a primary rhinoplasty that requires a humpectomy, the dorsal aspect of the
upper lateral cartilages is commonly discarded. Many of these patients need spreader grafts …
upper lateral cartilages is commonly discarded. Many of these patients need spreader grafts …
[HTML][HTML] Mutations of Human NARS2, Encoding the Mitochondrial Asparaginyl-tRNA Synthetase, Cause Nonsyndromic Deafness and Leigh Syndrome
Here we demonstrate association of variants in the mitochondrial asparaginyl-tRNA
synthetase NARS2 with human hearing loss and Leigh syndrome. A homozygous missense …
synthetase NARS2 with human hearing loss and Leigh syndrome. A homozygous missense …
[HTML][HTML] Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver
V Blanc, E Park, S Schaefer, M Miller, Y Lin, S Kennedy… - Genome biology, 2014 - Springer
Background RNA editing encompasses a post-transcriptional process in which the genomically
templated sequence is enzymatically altered and introduces a modified base into the …
templated sequence is enzymatically altered and introduces a modified base into the …
[HTML][HTML] Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes
Background A-to-I RNA editing diversifies the transcriptome and has multiple downstream
functional effects. Genetic variation contributes to RNA editing variability between individuals …
functional effects. Genetic variation contributes to RNA editing variability between individuals …
[HTML][HTML] Population and allelic variation of A-to-I RNA editing in human transcriptomes
Background A-to-I RNA editing is an important step in RNA processing in which specific
adenosines in some RNA molecules are post-transcriptionally modified to inosines. RNA editing …
adenosines in some RNA molecules are post-transcriptionally modified to inosines. RNA editing …
[HTML][HTML] The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA
The capacity for T cells to become activated and clonally expand during pathogen invasion
is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling …
is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling …
[PDF][PDF] Detecting allele-specific alternative splicing from population-scale RNA-seq data
RNA sequencing (RNA-seq) is a powerful technology for studying human transcriptome
variation. We introduce PAIRADISE (Paired Replicate Analysis of Allelic Differential Splicing …
variation. We introduce PAIRADISE (Paired Replicate Analysis of Allelic Differential Splicing …