Cancer testis antigens (CTAs) are an extensive gene family with a unique expression pattern
restricted to germ cells, but aberrantly reactivated in cancer tissues. Studies indicate that …

10.7554/eLife.47013.001 Monocyte counts are increased during human tuberculosis (TB)
but it has not been determined whether Mycobacterium tuberculosis (Mtb) directly regulates …

An L-amino acid oxidase from Peruvian Bothrops pictus (Bpic-LAAO) snake venom was purified
using a combination of size-exclusion and ion-exchange chromatography. Bpic-LAAO is …

Epitope identification is essential for developing effective antibodies that can detect and
neutralize bioactive proteins. Computational prediction is a valuable and time-saving alternative …

Background The humoral immune system response is based on the interaction between
antibodies and antigens for the clearance of pathogens and foreign molecules. The interaction …

Circulating extracellular vesicles (EVs) present in the bodily fluids of patients with cancer
may provide non-invasive access to the tumor tissue. Yet, the transcriptomic lineage of tumor-…

Extracellular vesicles (EVs) have brought great momentum to the non-invasive liquid biopsy
procedure for the detection, characterization, and monitoring of cancer. Despite the common …

Emerging evidence suggests that brain derived extracellular vesicles (EVs) and particles (EPs)
can cross blood-brain barrier and mediate communication among neurons, astrocytes, …

Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …

Cystectomy is a standard treatment for muscle-invasive bladder cancer (MIBC), but it is life-altering.
We initiated a phase 2 study in which patients with MIBC received four cycles of …