The identification of the antigen recognition receptors for innate immunity, most notably the
Toll-like receptors, has sparked great interest in therapeutic manipulation of the innate …

Asthma has been considered a T helper 2 (T H 2) cell-associated inflammatory disease, and
T H 2-type cytokines, such as interleukin-4 (IL-4), IL-5 and IL-13, are thought to drive the …

Highlights • Preclinical studies support us of PI3K inhibitors in autoimmunity and inflammation.
• First in class PI3K inhibitor has been approved for treatment of B cell lymphoma. • …

Mice without secreted TNF but with functional, normally regulated and expressed membrane-bound
TNF (memTNF Δ/Δ mice) were created by knocking-in the uncleavable Δ1-9,K11E …

Despite the prevalence and clinical importance of influenza, its long-term effect on lung
immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 …

Influenza A virus ( IAV )‐induced severe disease is characterized by infected lung epithelia,
robust inflammatory responses and acute lung injury. Since type I interferon ( IFN αβ) and …

In order to improve targeted therapeutic approaches for asthma patients, insights into the
molecular mechanisms that differentially contribute to disease phenotypes, such as obese …

A murine model of allergen-induced airway inflammation and epithelial phenotypic change,
and the time-courses of these events, are described. Mice were sensitized to ovalbumin …

Mice sensitized for a Th2 response to Leishmania LACK antigen developed allergic airway
inflammation upon exposure to LACK aerosol. Using multimers of IA d molecules bound to a …

LETTERS TO THE EDITOR 1491 at www. jacionline. org). Presumptive histamine-secreting
strains were further screened using quantitative PCR and ultraperformance liquid …