The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through
amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC …

Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating
the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of …

Small cell lung cancer (SCLC) is an aggressive disease with high mortality, and the identification
of effective pharmacological strategies to target SCLC biology represents an urgent …

Background Cowpea, Vigna unguiculata (L.) Walp., is one of the most important food and
forage legumes in the semi-arid tropics because of its drought tolerance and ability to grow on …

Irreversible inhibition of transcriptional cyclin-dependent kinases (CDKs) provides a therapeutic
strategy for cancers that rely on aberrant transcription; however, lack of understanding of …

The Wnt/β-catenin pathway is among the most frequently altered signaling networks in
human cancers. Despite decades of preclinical and clinical research, efficient therapeutic …

Neurogenesis is a highly-regulated process occurring in the dentate gyrus that has been
linked to learning, memory, and antidepressant efficacy. MicroRNAs (miRNAs) have been …

The JAK‐STAT (Janus kinase‐signal transducer and activator of transcription) signaling
pathway drives cellular growth, differentiation, and the immune response. STAT‐activated gene …

MYC is a well-characterized driver of numerous tumor types. Since the protein encoded by
this gene is challenging to target via conventional modalities, progress in new therapeutic …

Background Signal transducer and activator of transcription (STAT) activation of gene expression
is both rapid and transient, and when properly executed it affects growth, differentiation…