[HTML][HTML] Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease

…, DP Matheos, J Phan, DI Javonillo, KM Tran, E Hingco… - Scientific data, 2021 - nature.com
Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms
and testing interventions and therapeutics. For disorders such as Alzheimer’s disease in …

[HTML][HTML] Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's disease

DI Javonillo, KM Tran, J Phan, E Hingco… - Frontiers in …, 2022 - frontiersin.org
Animal models of disease are valuable resources for investigating pathogenic mechanisms
and potential therapeutic interventions. However, for complex disorders such as Alzheimer’s …

Perceptual correlates of neural representations evoked by odorant enantiomers

…, E Yue, A Morse, Z Xu, EE Hingco… - Journal of …, 2001 - Soc Neuroscience
Spatial activation patterns within the olfactory bulb are believed to contribute to the neural
representation of odorants. In this study, we attempted to predict the perceptions of odorants …

Multidimensional chemotopic responses to n‐aliphatic acid odorants in the rat olfactory bulb

BA Johnson, CC Woo, EE Hingco… - Journal of …, 1999 - Wiley Online Library
In an effort to understand the means by which similar chemical odorants are encoded in the
mammalian brain, we exposed rats to a homologous series of n‐aliphatic acids and mapped …

Functional mapping of the rat olfactory bulb using diverse odorants reveals modular responses to functional groups and hydrocarbon structural features

…, Z Xu, JS Yihan, S Yip, EE Hingco… - Journal of …, 2002 - Wiley Online Library
In an effort to understand the olfactory code of rats, we collected more than 1,500,000
measurements of glomerular activity in response to 54 odorants selected to provide differences in …

[HTML][HTML] Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS

…, AR Najafi, Y Ghorbanian, N Soni, EE Hingco… - Journal of …, 2020 - Springer
Background Microglia, the primary resident myeloid cells of the brain, play critical roles in
immune defense by maintaining tissue homeostasis and responding to injury or disease. …

[HTML][HTML] Remyelination is correlated with regulatory T cell induction following human embryoid body-derived neural precursor cell transplantation in a viral model of …

WC Plaisted, A Zavala, E Hingco, H Tran, R Coleman… - PloS one, 2016 - journals.plos.org
We have recently described sustained clinical recovery associated with dampened
neuroinflammation and remyelination following transplantation of neural precursor cells (NPCs) …

Exposure to a broad range of odorants decreases cell mortality in the olfactory bulb

CC Woo, EE Hingco, GE Taylor, M Leon - Neuroreport, 2006 - journals.lww.com
Experience with multiple odorants during early postnatal development increases the number
of cells in the olfactory bulb of rats. In this study, we asked whether at least part of this …

Broad activation of the glomerular layer enhances subsequent olfactory responses

CC Woo, EE Hingco, BA Johnson, M Leon - Chemical senses, 2007 - academic.oup.com
Early olfactory experience with a specific odorant enhances the subsequent response of the
glomerular layer of the rat olfactory bulb to that same odorant. Because different odorants …

Prolonged stimulus exposure reveals prolonged neurobehavioral response patterns

…, CC Woo, Y Zeng, Z Xu, EE Hingco… - Journal of …, 2010 - Wiley Online Library
Although it has been shown repeatedly that minimum response times in sensory systems
can be quite short, organisms more often continue to respond to sensory stimuli over …