Myocardial hypertrophy and dysfunction occur in response to excessive catecholaminergic
drive. Adverse cardiac remodelling is associated with activation of proinflammatory cytokines …

Background— The present study addresses the hypothesis that the activity of dipeptidyl
peptidase IV (DPPIV), an enzyme that inactivates peptides that possess cardioprotective actions, …

Background Cardiac cell transplantation is compromised by low cell retention and poor graft
viability. Here, the effects of co-injecting adipose tissue-derived stem cells (ASCs) with …

Background SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity,
regardless of the presence or absence of diabetes, but the mechanisms underlying this benefit …

Heart failure (HF) is associated with a reduced effective circulating volume that drives sodium
and water retention and extracellular volume expansion. We therefore hypothesized that …

BACKGROUND: The purpose of the current study was to create a model of myocardial infarction
(MI) that is homogeneous in size with a low immediate (24 hours) mortality. METHODS …

Aims Emerging evidence suggests the existence of a crosstalk between dipeptidyl peptidase
4 (DPP4) and the renin-angiotensin system (RAS). Therefore, combined inhibition of DPP4 …

OBJECTIVE: Exercise is a protective factor for cardiovascular morbidity and mortality, with
unclear mechanisms. Changing the myocardial metabolism causes harmful consequences for …

Background Sustained β‐adrenoreceptor activation promotes cardiac hypertrophy and cellular
injury. Aims To evaluate the cardioprotective effect of exercise on damage induced by β‐…

OBJETIVO: A relação temporal entre disfunção ventricular (DV) após infarto do miocárdio (IM)
e função mecânica do miocárdio remanescente não está estabelecida. O trabalho …