User profiles for Eduardo Gallardo Toledo

Eduardo Gallardo-Toledo

University of Liverpool
Verified email at liverpool.ac.uk
Cited by 335

Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches

…, F Morales, E Gallardo-Toledo… - International journal …, 2015 - Taylor & Francis
An exciting and emerging field in nanomedicine involves the use of gold nanoparticles (AuNPs)
in the preclinical development of new strategies for the treatment and diagnosis of brain-…

The influence of size and chemical composition of silver and gold nanoparticles on in vivo toxicity with potential applications to central nervous system diseases

DF Báez, E Gallardo-Toledo, MP Oyarzún… - International journal …, 2021 - Taylor & Francis
The physicochemical and optical properties of silver nanoparticles (SNPs) and gold
nanoparticles (GNPs) have allowed them to be employed for various biomedical applications, …

Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2

…, E Salas-Huenuleo, E Gallardo-Toledo… - …, 2017 - Future Medicine
Aim: To improve the in vivo delivery of gold nanorods (GNRs) to the central nervous system
of rats, these gold nanoparticles were conjugated to Angiopep-2, a shuttle peptide that can …

Intranasal administration of gold nanoparticles designed to target the central nervous system: fabrication and comparison between nanospheres and nanoprisms

E Gallardo-Toledo, A Tapia-Arellano, F Celis… - International Journal of …, 2020 - Elsevier
The presence of the blood–brain barrier (BBB) limit gold nanoparticles (GNP) accumulation
in central nervous system (CNS) after intravenous (IV) administration. The intranasal (IN) …

Transfersomes as alternative topical nanodosage forms for the treatment of skin disorders

P Oyarzún, E Gallardo-Toledo, J Morales… - Nanomedicine, 2021 - Future Medicine
Topical drug delivery is a promising approach to treat different skin disorders. However, it
remains a challenge mainly due to the nature and rigidity of the nanosystems, which limit deep …

[HTML][HTML] Evaluation of Nafamostat as chemoprophylaxis for SARS-CoV-2 infection in hamsters

M Neary, J Sharp, E Gallardo-Toledo, J Herriott, E Kijak… - Viruses, 2023 - mdpi.com
The successful development of a chemoprophylaxis against SARS-CoV-2 could provide a
tool for infection prevention that is implementable alongside vaccination programmes. …

Functionalization with PEG/Angiopep-2 peptide to improve the delivery of gold nanoprisms to central nervous system: In vitro and in vivo studies

A Tapia-Arellano, E Gallardo-Toledo, C Ortiz… - Materials Science and …, 2021 - Elsevier
One of main drawbacks for the treatment of neurodegenerative pathologies is ensuring the
delivery of therapeutic agents into the central nervous system (CNS). Nowadays, gold …

The curvature of gold nanoparticles influences the exposure of amyloid-β and modulates its aggregation process

A Tapia-Arellano, E Gallardo-Toledo, F Celis… - Materials Science and …, 2021 - Elsevier
Gold nanoparticles (GNP) are tunable nanomaterials that can be used to develop rational
therapeutic inhibitors against the formation of pathological aggregates of proteins. In the case …

[HTML][HTML] β-cyclodextrin-based nanosponges inclusion compounds associated with gold nanorods for potential NIR-II drug delivery

…, E Cortés-Adasme, E Gallardo-Toledo… - Pharmaceutics, 2022 - mdpi.com
This article describes the synthesis and characterization of two nanocarriers consisting of β-cyclodextrin-based
nanosponges (NSs) inclusion compounds (ICs) and gold nanorods (…

[HTML][HTML] Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters

E Gallardo-Toledo, M Neary, J Sharp, J Herriott, E Kijak… - Viruses, 2023 - mdpi.com
Pibrentasvir (PIB) has been demonstrated to block exonuclease activity of the SARS-CoV-2
polymerase, protecting favipiravir (FVP) and remdesivir (RDV) from post-incorporation …