Transcription factors and signaling molecules are well-known regulators of stem cell identity
and behavior; however, increasing evidence indicates that environmental cues contribute to …

LncRNAs have recently emerged as new and fundamental transcriptional and post-transcriptional
regulators acting at multiple levels of gene expression. Indeed, lncRNAs participate in …

In this paper, we summarize the current knowledge of the role of proline metabolism in the
control of the identity of Embryonic Stem Cells (ESCs). An imbalance in proline metabolism …

The molecular mechanisms controlling mouse embryonic stem cell (ESC) metastability, ie
their capacity to fluctuate between different states of pluripotency, are not fully resolved. We …

Floating spheroidal aggregates of mouse embryonic stem cells can develop into polarized/elongated
organoids, namely gastruloids. We set up a high-performing assay to measure …

3D embryonic stem cell (ESC) aggregates self-organize into embryo-like structures named
gastruloids that recapitulate the axial organization of post-implantation embryos. Crucial in …

Ultraconserved elements (UCEs) show the peculiar feature to retain extended perfect
sequence identity among human, mouse, and rat genomes. Most of them are transcribed and …

The power of embryonic stem cells (ESCs) lies in their ability to self-renew and differentiate.
Behind these two unique capabilities is a fine-tuned molecular network that shapes the …

Permeabilization with cetyl trimethyl ammonium bromide was used to study the post-translational
modification of the P II protein in Rhizobium leguminosarum. Upon incubation with …

Embryonic Stem Cells (ESCs) are of great interest for providing a resource to generate
useful cell types for transplantation or novel therapeutic studies. However, molecular events …