Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in
age-related metabolic decline. To date, the mechanism responsible for the age-related …

Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin
resistance and diabetes, but mechanisms underlying this relationship are unclear. Although …

Cellular senescence is a fundamental aging mechanism that has been implicated in many
age-related diseases and is a significant cause of tissue dysfunction. Accumulation of …

Nicotinamide adenine dinucleotide (NAD) plays key roles in many cellular functions. In addition
to its well-known role in energy metabolism, NAD also plays a role in signal transduction…

Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to
develop new strategies to treat this pathology. In the past years, the manipulation of NAD + …

Decreased NAD + levels have been shown to contribute to metabolic dysfunction during
aging. NAD + decline can be partially prevented by knockout of the enzyme CD38. However, it …

CD38 (Cluster of Differentiation 38) is a multifunctional ecto-enzyme that metabolizes NAD+
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …

Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies
show that a reduction in nicotinamide adenine dinucleotide (NAD + ) is a key factor for the …

Calcium controls a number of critical events, including motility, secretion, cell invasion and
egress by apicomplexan parasites 1 . Compared to animal 2 and plant cells 3 , the molecular …

CD38 is a multifunctional enzyme that uses nicotinamide adenine dinucleotide (NAD) as a
substrate to generate second messengers. Recently, CD38 was also identified as one of the …