User profiles for Eduardo R. Cobo

Eduardo R. Cobo

University of Calgary
Verified email at ucalgary.ca
Cited by 2198

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

…, D Parsonage, RM Andrade, C He, ER Cobo… - Nature medicine, 2012 - nature.com
Entamoeba histolytica, a protozoan intestinal parasite, is the causative agent of human
amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of …

A review of sexually transmitted bovine trichomoniasis and campylobacteriosis affecting cattle reproductive health

AN Michi, PH Favetto, J Kastelic, ER Cobo - Theriogenology, 2016 - Elsevier
The objective is to discuss sexually transmitted diseases caused by Tritrichomonas foetus (T
foetus) and Campylobacter fetus (C fetus) subsp. venerealis, with a focus on prevalence, …

[HTML][HTML] Antimicrobial human β-defensins in the colon and their role in infectious and non-infectious diseases

ER Cobo, K Chadee - Pathogens, 2013 - mdpi.com
β-defensins are small cationic antimicrobial peptides secreted by diverse cell types including
colonic epithelial cells. Human β-defensins form an essential component of the intestinal …

MUC2 mucin and butyrate contribute to the synthesis of the antimicrobial peptide cathelicidin in response to Entamoeba histolytica-and dextran sodium sulfate …

ER Cobo, V Kissoon-Singh, F Moreau… - Infection and …, 2017 - Am Soc Microbiol
Embedded in the colonic mucus are cathelicidins, small cationic peptides secreted by colonic
epithelial cells. Humans and mice have one cathelicidin-related antimicrobial peptide (…

[HTML][HTML] Host innate immune responses and microbiome profile of neonatal calves challenged with Cryptosporidium parvum and the effect of bovine colostrum …

…, DE Gomez, MC Windeyer, ER Cobo - Frontiers in cellular …, 2023 - frontiersin.org
Calves are highly susceptible to gastrointestinal infection with Cryptosporidium parvum (C.
parvum), which can result in watery diarrhea and eventually death or impaired development. …

Host defense cathelicidins in cattle: types, production, bioactive functions and potential therapeutic and diagnostic applications

…, PA Cavalcante, HW Barkema, ER Cobo - International journal of …, 2018 - Elsevier
Cathelicidins are a primitive class of host defense peptides and are known for their broad–spectrum
antimicrobial activity against bacteria, fungi, and enveloped viruses. These small, …

[HTML][HTML] Molecular epidemiology and distribution of antimicrobial resistance genes of Staphylococcus species isolated from Chinese dairy cows with clinical mastitis

Y Qu, H Zhao, DB Nobrega, ER Cobo, B Han… - Journal of dairy …, 2019 - Elsevier
Staphylococcus species, categorized into Staphylococcus aureus and non-aureus
staphylococci (NAS), are frequent causes of mastitis in dairy cattle around the world. Current …

Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity

…, DY Cheung, R Lozano, ER Cobo… - Proceedings of the …, 2013 - National Acad Sciences
Metronidazole and other 5-nitroimidazoles (5-NI) are among the most effective antimicrobials
available against many important anaerobic pathogens, but evolving resistance is …

[HTML][HTML] The network of colonic host defense peptides as an innate immune defense against enteropathogenic bacteria

GAD Blyth, L Connors, C Fodor, ER Cobo - Frontiers in immunology, 2020 - frontiersin.org
Host defense peptides, abundantly secreted by colonic epithelial cells and leukocytes, are
proposed to be critical components of an innate immune response in the colon against …

[HTML][HTML] Klebsiella pneumoniae isolated from bovine mastitis is cytopathogenic for bovine mammary epithelial cells

J Cheng, J Zhang, B Han, HW Barkema, ER Cobo… - Journal of dairy …, 2020 - Elsevier
Klebsiella pneumoniae, a common cause of clinical mastitis (CM) in dairy cows, can cause
severe clinical symptoms. However, its pathogenicity in the bovine mammary gland is not …