User profiles for Edward F Chang

Edward F Chang

University of California, San Francisco
Verified email at neurosurg.ucsf.edu
Cited by 36618

Phonetic feature encoding in human superior temporal gyrus

N Mesgarani, C Cheung, K Johnson, EF Chang - Science, 2014 - science.org
During speech perception, linguistic elements such as consonants and vowels are extracted
from a complex acoustic speech signal. The superior temporal gyrus (STG) participates in …

Functional organization of human sensorimotor cortex for speech articulation

KE Bouchard, N Mesgarani, K Johnson, EF Chang - Nature, 2013 - nature.com
Speaking is one of the most complex actions that we perform, but nearly all of us learn to do
it effortlessly. Production of fluent speech requires the precise, coordinated movement of …

[PDF][PDF] Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse

…, PD Blumenthal, H Vogel, GK Steinberg, MSB Edwards… - Neuron, 2016 - cell.com
The functional and molecular similarities and distinctions between human and murine astrocytes
are poorly understood. Here, we report the development of an immunopanning method …

New tools for studying microglia in the mouse and human CNS

…, A Tucker, IL Weissman, EF Chang… - Proceedings of the …, 2016 - National Acad Sciences
The specific function of microglia, the tissue resident macrophages of the brain and spinal
cord, has been difficult to ascertain because of a lack of tools to distinguish microglia from …

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

…, D James, S Mayer, J Chang, KI Auguste, EF Chang… - Nature, 2018 - nature.com
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the
adult mammalian hippocampus 1 , 2 , 3 , 4 , 5 . This process has been linked to learning and …

[PDF][PDF] Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas

…, EF Chang, KR Lamborn, SM Chang… - Journal of Clinical …, 2008 - researchgate.net
Chang EF, Keles GE, Potts MB, et al: Seizure characteristics and control following
surgical resection in 332 patients with low-grade glioma. J Neurosurg (in press) … Duffau H …

Selective cortical representation of attended speaker in multi-talker speech perception

N Mesgarani, EF Chang - Nature, 2012 - nature.com
Humans possess a remarkable ability to attend to a single speaker’s voice in a multi-talker
background 1 , 2 , 3 . How the auditory system manages to extract intelligible speech under …

[HTML][HTML] Neuroprosthesis for decoding speech in a paralyzed person with anarthria

…, A Tu-Chan, K Ganguly, EF Chang - … England Journal of …, 2021 - Mass Medical Soc
Background Technology to restore the ability to communicate in paralyzed persons who
cannot speak has the potential to improve autonomy and quality of life. An approach that …

Closed-loop neuromodulation in an individual with treatment-resistant depression

…, HE Dawes, PA Starr, AD Krystal, EF Chang - Nature medicine, 2021 - nature.com
Deep brain stimulation is a promising treatment for neuropsychiatric conditions such as
major depression. It could be optimized by identifying neural biomarkers that trigger therapy …

Speech synthesis from neural decoding of spoken sentences

GK Anumanchipalli, J Chartier, EF Chang - Nature, 2019 - nature.com
Technology that translates neural activity into speech would be transformative for people who
are unable to communicate as a result of neurological impairments. Decoding speech from …