Autoimmune diseases are common and debilitating, but their severe manifestations could
be reduced if biomarkers were available to allow individual tailoring of potentially toxic …

Detailed population-level description of the human immune system has recently become
achievable. We used a 'systems-level' approach to establish a resource of cellular immune …

In the 18th century, Thomas Bayes developed his eponymous theorem that teaches us that
pretest probabilities can be altered by new information, such as when game show host Monty …

The magnitude and quality of the germinal center (GC) response decline with age, resulting
in poor vaccine-induced immunity in older individuals. A functional GC requires the co-…

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease more prevalent
in people of African and Asian origin than Caucasian origin. FcγRIIb is an inhibitory Fc …

The effects of the coronavirus disease-2019 (COVID-19) pandemic, particularly among those
with chronic kidney disease (CKD), who commonly have defects in humoral and cellular …

Patients with cancer are at greater risk of severe COVID-19 and have been prioritised for
COVID-19 vaccination globally. We previously showed that following two doses of COVID-19 …

We sought to compare neutralising antibody responses between seronaive haemodialysis
patients and the healthy individuals we have already reported on as part of the Legacy study. …

T follicular regulatory (Tfr) cells are a subset of Foxp3 + regulatory T (Treg) cells that form in
response to immunization or infection, which localize to the germinal centre where they …

… Wall,3,9 Edward J. Carr,10 Sina Namjou,11 Simon Caidan,11 Mike Gavrielides,12 James
I. MacRae,13 Gavin Kelly,14 Kema Peat,2 Denise Kelly,2 Aida Murra,2 Kayleigh Kelly,2 Molly …