Chemokines have a central role in regulating processes essential to the immune function of
T cells 1 , 2 , 3 , such as their migration within lymphoid tissues and targeting of pathogens in …

The cell nucleus must continually resist and respond to intercellular and intracellular mechanical
forces to transduce mechanical signals and maintain proper genome organization and …

Nuclear shape and architecture influence gene localization, mechanotransduction, transcription,
and cell function. Abnormal nuclear morphology and protrusions termed “blebs” are …

Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops. “Loop extrusion” can be impeded by chromatin-bound factors, such as CTCF, …

The cell nucleus encloses, organizes, and protects the genome. Chromatin maintains
nuclear mechanical stability and shape in coordination with lamins and the cytoskeleton. …

Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …

Our understanding of the physical principles organizing the genome in the nucleus is limited
by the lack of tools to directly exert and measure forces on interphase chromosomes in vivo …

Chromosomes are organized as chromatin loops that promote segregation, enhancer-promoter
interactions, and other genomic functions. Loops were hypothesized to form by ‘loop …

Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …

SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell
cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and …