Evolutionary studies necessary to dissect diverse biological processes have been limited by
the lack of reverse genetic approaches in most organisms with sequenced genomes. We …

The three-dimensional organization of a genome plays a critical role in regulating gene
expression, yet little is known about the machinery and mechanisms that determine higher-order …

Exploitation of custom-designed nucleases to induce DNA double-strand breaks (DSBs) at
genomic locations of choice has transformed our ability to edit genomes, regardless of their …

Male infertility is a long-standing enigma of significant medical concern. The integrity of
sperm chromatin is a clinical indicator of male fertility and in vitro fertilization potential 1 : …

To reveal impacts of sexual mode on genome content, we compared chromosome-scale
assemblies of the outcrossing nematode Caenorhabditis nigoni to its self-fertile sibling species, …

In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of
one sex to equalize levels of X-gene products between males (1X) and females (2X). Here …

Ablation of cells by the controlled expression of a lethal gene can be used to engineer plant
traits such as male sterility and disease resistance. However, it may not be possible to …

Organisms that count X-chromosome number to determine sex utilize dosage compensation
mechanisms to balance X-gene expression between sexes. Typically, a regulatory complex …

This important study uses state-of-the-art methods to explore the evolution of dosage
compensation between two closely related nematode species. The evidence supporting the rapid …

Hydroponic growth medium must be well buffered if it is to support sustained plant growth.
Although 1.0 millimolar phosphate is commonly used as a buffer for hydroponic growth media, …