Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position paper…

Computer models offer many attractive benefits. However, the modeling of cardiac tissue is
computationally expensive due to several physical constraints which result in fine …

Classical concepts of atrial fibrillation (AF) have been rooted in Moe’s multiple-wavelet
hypothesis and simple cellular-automaton computer model. Recent experimental work has raised …

Aims The mechanisms underlying persistent atrial fibrillation (AF) in patients with atrial fibrosis
are poorly understood. The goal of this study was to use patient-derived atrial models to …

The bidomain equations are the most complete description of cardiac electrical activity. Their
numerical solution is, however, computationally demanding, especially in three dimensions…

Background and Objective: Cardiac electrophysiology is a medical specialty with a long and
rich tradition of computational modeling. Nevertheless, no community standard for cardiac …

Cardiac digital twins (Cardiac Digital Twin (CDT)s) of human electrophysiology (Electrophysiology
(EP)) are digital replicas of patient hearts derived from clinical data that match like-for-…

Anatomically accurate and biophysically detailed bidomain models of the human heart have
proven a powerful tool for gaining quantitative insight into the links between electrical …

The mechanisms by which Na + -channel blocking antiarrhythmic drugs terminate atrial
fibrillation (AF) remain unclear. Classical “leading-circle” theory suggests that Na + -channel …

The bidomain equations are considered to be one of the most complete descriptions of the
electrical activity in cardiac tissue, but large scale simulations, as resulting from discretization …