To understand the pathogenesis of chronic inflammatory disease, we analyzed an
experimental mouse model of chronic lung disease with pathology that resembles asthma and …

Invariant natural killer T cells (iNKT cells) have a prominent role during infection and other
inflammatory processes, and these cells can be activated through their T cell antigen …

Host defense against viruses probably depends on targeted death of infected host cells and
then clearance of cellular corpses by macrophages. For this process to be effective, the …

Epithelial hyperplasia and metaplasia are common features of inflammatory and neoplastic
disease, but the basis for the altered epithelial phenotype is often uncertain. Here we show …

A complete chart of cis-regulatory elements and their dynamic activity is necessary to
understand the transcriptional basis of differentiation and function of an organ system. We …

Respiratory viral infections are associated with an increased risk of asthma, but how acute
Th1 antiviral immune responses lead to chronic inflammatory Th2 disease remains undefined. …

In this single-center, retrospective cohort analysis of hospitalized coronavirus disease 2019 (COVID-19)
patients, we investigate whether inflammatory biomarker levels predict …

Background Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis,
inflammatory bowel disease, interstitial lung disease, and Sjögren's syndrome and …

Background: The efficacy and safety of prophylactic full-dose anticoagulation and antiplatelet
therapy in critically ill COVID-19 patients remain uncertain. Methods: COVID-PACT (…

iNKT cells are innate T lymphocytes recognizing endogenous and foreign lipid antigens
presented in the MHC-like molecule CD1d. The semi-invariant iNKT cell TCR can detect certain …