The endoplasmic reticulum (ER) is dedicated to import, folding and assembly of all proteins
that travel along or reside in the secretory pathway of eukaryotic cells. Folding in the ER is …

Homeostasis of the protein folding machinery in the endoplasmic reticulum (ER) is maintained
via several parallel unfolded protein response pathways that are remarkably conserved …

The unfolded protein response (UPR) is an intracellular signaling pathway that counteracts
variable stresses that impair protein folding in the endoplasmic reticulum (ER). As such, the …

Deficiencies in the protein-folding capacity of the endoplasmic reticulum (ER) in all eukaryotic
cells lead to ER stress and trigger the unfolded protein response (UPR) 1 , 2 , 3 . ER stress …

Upon encounter with antigen, B lymphocytes differentiate into Ig-secreting plasma cells.
This step involves a massive development of secretory organelles, most notably the …

Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐mediated
mechanisms. Procollagens, the most abundant gene products in Metazoa, are …

Maintenance of cellular proteostasis relies on efficient clearance of defective gene products.
For misfolded secretory proteins, this involves dislocation from the endoplasmic reticulum ( …

RAB39B is a member of the RAB family of small GTPases that controls intracellular vesicular
trafficking in a compartment-specific manner. Mutations in the RAB39B gene cause …

Viral glycoproteins fold and oligomerize in the endoplasmic reticulum of the host cell. They
employ the cellular machinery and receive assistance from cellular folding factors. During the …

To warrant the quality of the secretory proteome, stringent control systems operate at the
endoplasmic reticulum (ER)-Golgi interface, preventing the release of nonnative products. …