Recent evidence suggests that neuronal plasticity plays an important role in the recovery
from depression. Antidepressant drugs and electroconvulsive shock treatment increase the …

Major depression is associated with reduced volumes in the hippocampus and prefrontal
cortex, whereas antidepressant treatments promote several forms of neuronal plasticity, …

Antidepressants increase proliferation of neuronal progenitor cells and expression of brain-derived
neurotrophic factor (BDNF) in the hippocampus. We investigated the role of BDNF …

The past decade has witnessed a growing interest in the trophic effects of antidepressant
drugs. Antidepressants stimulate the production and signaling of plasticity-related proteins …

The chemical hypothesis of depression suggests that mood disorders are caused by a
chemical imbalance in the brain, which can be corrected by antidepressant drugs. However, …

Previous studies suggest that brain-derived neurotrophic factor and its receptor TrkB are
critically involved in the therapeutic actions of antidepressant drugs. We have previously shown …

Accumulating evidence suggests that biogenic amine-based antidepressants act, at least in
part, via regulation of brain-derived neurotrophic factor (BDNF) signaling. Biogenic amine-…

We investigated whether fluoxetine, a widely prescribed medication for treatment of depression,
restores neuronal plasticity in the adult visual system of the rat. We found that chronic …

Recent studies have indicated that exogenously administered neurotrophins produce
antidepressant-like behavioral effects. We have here investigated the role of endogenous brain-…

Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …