Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive
analysis of the immune system. In this Review, we briefly describe the available scRNA-seq …

The expression of inhibitory immune checkpoint molecules, such as programmed death-ligand
(PD-L)1, is frequently observed in human cancers and can lead to the suppression of T …

Multimodal single-cell assays provide high-resolution snapshots of complex cell populations,
but are mostly limited to transcriptome plus an additional modality. Here, we describe …

Computational single-cell RNA-seq (scRNA-seq) methods have been successfully applied to
experiments representing a single condition, technology, or species to discover and define …

The simultaneous measurement of multiple modalities represents an exciting frontier for
single-cell genomics and necessitates computational methods that can define cellular states …

Single-cell transcriptomics has transformed our ability to characterize cell states, but deep
biological understanding requires more than a taxonomic listing of clusters. As new methods …

The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex
that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 …

Genetic and functional studies underscore the central role of JAK/STAT signaling in
myeloproliferative neoplasms (MPNs). However, the mechanisms that mediate transformation in …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we …

Cohesin complex members have recently been identified as putative tumor suppressors in
hematologic and epithelial malignancies. The cohesin complex guides chromosome …