Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength
Skeletal muscle weakness occurs with aging and in females this is compounded by the loss
of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle …
of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle …
Muscle and bone mass in middle‐aged women: role of menopausal status and physical activity
…, UM Kujala, V Kovanen, EK Laakkonen - Journal of cachexia …, 2020 - Wiley Online Library
Background Women experience drastic hormonal changes during midlife due to the
menopausal transition. Menopausal hormonal changes are known to lead to bone loss and …
menopausal transition. Menopausal hormonal changes are known to lead to bone loss and …
[HTML][HTML] Physical performance in relation to menopause status and physical activity
D Bondarev, EK Laakkonen, T Finni, K Kokko… - Menopause, 2018 - journals.lww.com
Objective: The aim of this study was to examine differences in physical performance (muscle
power, muscle strength, aerobic capacity, and walking speed) across menopausal stages …
power, muscle strength, aerobic capacity, and walking speed) across menopausal stages …
[HTML][HTML] Metabolic health, menopause, and physical activity—a 4-year follow-up study
Background In women, metabolic health deteriorates after menopause, and the role of
physical activity (PA) in mitigating the change is not completely understood. This study …
physical activity (PA) in mitigating the change is not completely understood. This study …
[PDF][PDF] Estrogen regulates the satellite cell compartment in females
…, CA Cabelka, NL Nash, HK Juppi, EK Laakkonen… - Cell reports, 2019 - cell.com
Skeletal muscle mass, strength, and regenerative capacity decline with age, with many
measures showing a greater deterioration in females around the time estrogen levels decrease …
measures showing a greater deterioration in females around the time estrogen levels decrease …
The older Finnish Twin Cohort—45 years of follow-up
…, V Kovanen, U Kujala, EK Laakkonen… - Twin Research and …, 2019 - cambridge.org
The older Finnish Twin Cohort (FTC) was established in 1974. The baseline survey was in
1975, with two follow-up health surveys in 1981 and 1990. The fourth wave of assessments …
1975, with two follow-up health surveys in 1981 and 1990. The fourth wave of assessments …
[HTML][HTML] Role of menopausal transition and physical activity in loss of lean and muscle mass: a follow-up study in middle-aged Finnish women
…, V Kovanen, UM Kujala, EK Laakkonen - Journal of clinical …, 2020 - mdpi.com
In midlife, women experience hormonal changes due to menopausal transition. A decrease
especially in estradiol has been hypothesized to cause loss of muscle mass. This study …
especially in estradiol has been hypothesized to cause loss of muscle mass. This study …
[HTML][HTML] Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort: novel results show menopause …
Objective: The multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study
was designed to reveal how hormonal differences over the menopausal stages affect the …
was designed to reveal how hormonal differences over the menopausal stages affect the …
Total and regional body adiposity increases during menopause—evidence from a follow‐up study
…, V Kovanen, S Karvinen, EK Laakkonen - Aging …, 2022 - Wiley Online Library
For women, menopausal transition is a time of significant hormonal changes, which may
contribute to altered body composition and regional adipose tissue accumulation. Excess …
contribute to altered body composition and regional adipose tissue accumulation. Excess …
Menopause modulates the circulating metabolome: evidence from a prospective cohort study
…, P Aukee, V Kovanen, EK Laakkonen - European Journal of …, 2022 - academic.oup.com
Aims We studied the changes in the circulating metabolome and their relation to the menopausal
hormonal shift in 17β-oestradiol and follicle-stimulating hormone levels among women …
hormonal shift in 17β-oestradiol and follicle-stimulating hormone levels among women …