Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength

BC Collins, EK Laakkonen, DA Lowe - Bone, 2019 - Elsevier
Skeletal muscle weakness occurs with aging and in females this is compounded by the loss
of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle …

Muscle and bone mass in middle‐aged women: role of menopausal status and physical activity

…, UM Kujala, V Kovanen, EK Laakkonen - Journal of cachexia …, 2020 - Wiley Online Library
Background Women experience drastic hormonal changes during midlife due to the
menopausal transition. Menopausal hormonal changes are known to lead to bone loss and …

[HTML][HTML] Physical performance in relation to menopause status and physical activity

D Bondarev, EK Laakkonen, T Finni, K Kokko… - Menopause, 2018 - journals.lww.com
Objective: The aim of this study was to examine differences in physical performance (muscle
power, muscle strength, aerobic capacity, and walking speed) across menopausal stages …

[HTML][HTML] Metabolic health, menopause, and physical activity—a 4-year follow-up study

…, T Rantalainen, S Sipilä, EK Laakkonen - International Journal of …, 2022 - nature.com
Background In women, metabolic health deteriorates after menopause, and the role of
physical activity (PA) in mitigating the change is not completely understood. This study …

[PDF][PDF] Estrogen regulates the satellite cell compartment in females

…, CA Cabelka, NL Nash, HK Juppi, EK Laakkonen… - Cell reports, 2019 - cell.com
Skeletal muscle mass, strength, and regenerative capacity decline with age, with many
measures showing a greater deterioration in females around the time estrogen levels decrease …

The older Finnish Twin Cohort—45 years of follow-up

…, V Kovanen, U Kujala, EK Laakkonen… - Twin Research and …, 2019 - cambridge.org
The older Finnish Twin Cohort (FTC) was established in 1974. The baseline survey was in
1975, with two follow-up health surveys in 1981 and 1990. The fourth wave of assessments …

[HTML][HTML] Role of menopausal transition and physical activity in loss of lean and muscle mass: a follow-up study in middle-aged Finnish women

…, V Kovanen, UM Kujala, EK Laakkonen - Journal of clinical …, 2020 - mdpi.com
In midlife, women experience hormonal changes due to menopausal transition. A decrease
especially in estradiol has been hypothesized to cause loss of muscle mass. This study …

[HTML][HTML] Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort: novel results show menopause …

…, T Tammelin, UM Kujala, S Sipilä, EK Laakkonen - Menopause, 2018 - journals.lww.com
Objective: The multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study
was designed to reveal how hormonal differences over the menopausal stages affect the …

Total and regional body adiposity increases during menopause—evidence from a follow‐up study

…, V Kovanen, S Karvinen, EK Laakkonen - Aging …, 2022 - Wiley Online Library
For women, menopausal transition is a time of significant hormonal changes, which may
contribute to altered body composition and regional adipose tissue accumulation. Excess …

Menopause modulates the circulating metabolome: evidence from a prospective cohort study

…, P Aukee, V Kovanen, EK Laakkonen - European Journal of …, 2022 - academic.oup.com
Aims We studied the changes in the circulating metabolome and their relation to the menopausal
hormonal shift in 17β-oestradiol and follicle-stimulating hormone levels among women …