Routing and spectrum allocation in elastic optical networks: A tutorial
Flexgrid technology is now considered to be a promising solution for future high-speed
network design. In this context, we need a tutorial that covers the key aspects of elastic optical …
network design. In this context, we need a tutorial that covers the key aspects of elastic optical …
Deregulation of the Akt pathway in human cancer
E Tokunaga, E Oki, A Egashira… - Current cancer drug …, 2008 - ingentaconnect.com
Akt (protein kinase B) is a serine/threonine kinase which is a central regulator of widely
divergent cellular processes including proliferation, differentiation, migration, survival and …
divergent cellular processes including proliferation, differentiation, migration, survival and …
Activation of PI3K/Akt signaling and hormone resistance in breast cancer
E Tokunaga, Y Kimura, K Mashino, E Oki, A Kataoka… - Breast cancer, 2006 - Springer
Akt is a serine/threonine kinase that has been demonstrated to play an important role in
survival when cells are exposed to different apoptotic stimuli. Recent studies show that aberrant …
survival when cells are exposed to different apoptotic stimuli. Recent studies show that aberrant …
[HTML][HTML] Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer
D Kotani, E Oki, Y Nakamura, H Yukami, S Mishima… - Nature medicine, 2023 - nature.com
Despite standard-of-care treatment, more than 30% of patients with resectable colorectal
cancer (CRC) relapse. Circulating tumor DNA (ctDNA) analysis may enable postsurgical risk …
cancer (CRC) relapse. Circulating tumor DNA (ctDNA) analysis may enable postsurgical risk …
Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies
…, J Furuse, T Denda, H Kawakami, E Oki… - Nature medicine, 2020 - nature.com
Comprehensive genomic profiling enables genomic biomarker detection in advanced solid
tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we …
tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we …
Panitumumab vs bevacizumab added to standard first-line chemotherapy and overall survival among patients with RAS wild-type, left-sided metastatic colorectal …
…, N Akazawa, H Ojima, Y Yuasa, K Miwa, H Yasui, E Oki… - JAMA, 2023 - jamanetwork.com
Importance For patients withRASwild-type metastatic colorectal cancer, adding anti–epidermal
growth factor receptor (anti-EGFR) or anti–vascular endothelial growth factor (anti-VEGF) …
growth factor receptor (anti-EGFR) or anti–vascular endothelial growth factor (anti-VEGF) …
Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six …
…, D Vernerey, J Meyers, A Harkin, V Torri, E Oki… - The lancet …, 2020 - thelancet.com
Background A prospective, pooled analysis of six randomised phase 3 trials was done to
investigate disease-free survival regarding non-inferiority of 3 months versus 6 months of …
investigate disease-free survival regarding non-inferiority of 3 months versus 6 months of …
Prognostic nutritional index predicts severe complications, recurrence, and poor prognosis in patients with colorectal cancer undergoing primary tumor resection
…, Y Miyamoto, N Yoshida, E Oki… - Diseases of the Colon …, 2015 - journals.lww.com
BACKGROUND: The prognostic nutritional index is reportedly related to postoperative
outcomes. OBJECTIVE: The aim of this study was to elucidate the clinical importance of the …
outcomes. OBJECTIVE: The aim of this study was to elucidate the clinical importance of the …
Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
The role of KRAS, when activated through canonical mutations, has been well established
in cancer 1 . Here we explore a secondary means of KRAS activation in cancer: focal high-…
in cancer 1 . Here we explore a secondary means of KRAS activation in cancer: focal high-…
Fragmentation problems and management approaches in elastic optical networks: A survey
Bandwidth fragmentation, a serious issue in elastic optical networks (EONs), can be suppressed
by proper management in order to enhance the accommodated traffic demands. In this …
by proper management in order to enhance the accommodated traffic demands. In this …