Basal forebrain atrophy along the Alzheimer's disease spectrum and its relevance for subjective cognitive decline
…, A Schneider, A Spottke, BH Schott, EJ Spruth… - 2020 - researchsquare.com
Background There is growing evidence in the literature that the cholinergic basal forebrain
might be one of the earliest affected structures in Alzheimer’s disease (AD). Recent data …
might be one of the earliest affected structures in Alzheimer’s disease (AD). Recent data …
Mediterranean diet, Alzheimer disease biomarkers, and brain atrophy in old age
…, N Roy, K Scheffler, A Schneider, A Spottke, EJ Spruth… - Neurology, 2021 - AAN Enterprises
Objective To determine whether following a Mediterranean-like diet (MeDi) relates to
cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross-sectional …
cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross-sectional …
[HTML][HTML] Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE)
Background Deep phenotyping and longitudinal assessment of predementia at-risk states
of Alzheimer’s disease (AD) are required to define populations and outcomes for dementia …
of Alzheimer’s disease (AD) are required to define populations and outcomes for dementia …
Minor neuropsychological deficits in patients with subjective cognitive decline
…, J Guski, A Polcher, I Frommann, S Roeske, EJ Spruth… - Neurology, 2020 - AAN Enterprises
Objective To determine the nature and extent of minor neuropsychological deficits in patients
with subjective cognitive decline (SCD) and their association with CSF biomarkers of …
with subjective cognitive decline (SCD) and their association with CSF biomarkers of …
Novelty-related fMRI responses of precuneus and medial temporal regions in individuals at risk for Alzheimer disease
…, K Scheffler, A Schneider, A Spottke, EJ Spruth… - Neurology, 2022 - AAN Enterprises
Background and Objectives We assessed whether novelty-related fMRI activity in medial
temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the …
temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the …
Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction
We investigated whether the impact of tau-pathology on memory performance and on
hippocampal/medial temporal memory function in non-demented individuals depends on the …
hippocampal/medial temporal memory function in non-demented individuals depends on the …
[HTML][HTML] Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia
Background White matter hyperintensities (WMH), a biomarker of small vessel disease, are
often found in Alzheimer’s disease (AD) and their advanced detection and quantification can …
often found in Alzheimer’s disease (AD) and their advanced detection and quantification can …
Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment
…, D Diesing, S Li, J Priller, EJ Spruth… - Alzheimer's & …, 2019 - Wiley Online Library
Introduction Impaired long‐term memory is a defining feature of mild cognitive impairment (MCI).
We tested whether this impairment is item specific, limited to some memoranda, …
We tested whether this impairment is item specific, limited to some memoranda, …
CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume
…, D Diesing, S Li, J Priller, EJ Spruth… - Alzheimer's & …, 2018 - Wiley Online Library
Introduction We examined the association between cerebrospinal fluid (CSF) biomarkers of
Alzheimer's disease, neural novelty responses, and brain volume in predementia old age. …
Alzheimer's disease, neural novelty responses, and brain volume in predementia old age. …
Linking early-life bilingualism and cognitive advantage in older adulthood
…, A Schneider, BH Schott, A Spottke, EJ Spruth… - Neurobiology of …, 2023 - Elsevier
Previous studies have identified bilingualism as a protective factor against dementia. Here
we aimed to test whether being bilingual at different life stages impacts cognition and brain …
we aimed to test whether being bilingual at different life stages impacts cognition and brain …