Background. The McCune-Albright syndrome is a sporadic disease characterized by
polyostotic fibrous dysplasia, café au lait spots, sexual precocity, and hyperfunction of multiple …

Answer questions and earn CME/CNE Recent decades have seen an unprecedented rise
in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more …

ContextWomen with BRCA1 or BRCA2 mutation are often advised to undergo preventive
oophorectomy. The effectiveness of this intervention has not been prospectively evaluated in a …

Importance Limited information about the relationship between specific mutations
inBRCA1orBRCA2(BRCA1/2) and cancer risk exists. Objective To identify mutation-specific cancer …

Purpose The purpose of this study was to estimate the extent of protection offered against
breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to …

Background Multiparity and the use of oral contraceptives reduce the risk of ovarian cancer,
but their effects on this risk in women with a BRCA1 or BRCA2 mutation are unclear. …

Several options for cancer prevention are available for women with a BRCA1 or BRCA2
mutation, including prophylactic surgery, chemoprevention and screening. The authors report …

Background: Oral contraceptive use has been associated with an increase in the risk of breast
cancer in young women. We examined whether this association is seen in women at high …

The early appearance of monoamine systems in the developing mammalian CNS suggests
that they play a role in neural development. We review data from two model systems that …

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this
risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 …