Cellular metabolism, the integrated interconversion of thousands of metabolic substrates
through enzyme-catalysed biochemical reactions, is the most investigated complex intracellular …

While current studies on complex networks focus on systems that change relatively slowly in
time, the structure of the most visited regions of the web is altered at the time scale from …

A set of highly connected proteins (or hubs) plays an important role for the integrity of the
protein interaction network of Saccharomyces cerevisae by connecting the network's intrinsic …

Mortality due to multidrug-resistant Staphylococcus aureus infection is predicted to surpass
that of human immunodeficiency virus/AIDS in the United States. Despite the various …

Humans differ from other primates by marked differences in cognitive abilities and a significantly
larger brain. These differences correlate with metabolic changes, as evidenced by the …

Many complex systems can be represented and analyzed as networks, and examples that
have benefited from this approach span the natural sciences. For instance, we now know that …

Understanding the system-level adaptive changes taking place in an organism in response
to variations in the environment is a key issue of contemporary biology. Current modeling …

An important goal of medical research is to develop methods to recover the loss of cellular
function due to mutations and other defects. Many approaches based on gene therapy aim to …

Electromagnetic wave theory is used to predict the radiation forces exerted upon a
micrometer-sized spherical particle illuminated by evanescent waves penetrating across a dielectric …

The reconstruction and analysis of genome-scale metabolic models constitutes a powerful
systems biology approach, with applications ranging from basic understanding of genotype-…