Replication is the cornerstone of a cumulative science [1]. However, new tools and
technologies, massive amounts of data, interdisciplinary approaches, and the complexity of the …

We have carried out automated extraction of explicit and implicit biomedical knowledge from
publicly available gene and text databases to create a gene-to-gene co-citation network for …

Although microRNAs (miRNAs) are among the most intensively studied molecules of the past
20 years, determining what is and what is not a miRNA has not been straightforward. Here, …

In 1994 we described a list of ∼2500 point mutations in the p53 gene of human tumors and
cell lines which we had compiled from the published literature and made available …

Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive
both their first and subsequent cancers, resulting in a growing number of older patients with …

Objective Estimates of cancer risk and the effects of surveillance in Lynch syndrome have
been subject to bias, partly through reliance on retrospective studies. We sought to establish …

Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome
and result in different but imprecisely known cancer risks. This study aimed to provide …

As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full
understanding of the variables affecting sequencing analysis output is required. Here using …

In recent years, there has been an exponential increase in the number of p53 mutations
identified in human cancers. The p53 mutation database consists of a list of point mutations in …

Removal of, or adjustment for, batch effects or center differences is generally required when
such effects are present in data. In particular, when preparing microarray gene expression …