INTRODUCTION Many complex human phenotypes, including diseases, exhibit sex-differentiated
characteristics. These sex differences have been variously attributed to hormones, …

Background & Aims Tight junction dysregulation and epithelial damage contribute to barrier
loss in patients with inflammatory bowel disease. However, the mechanisms that regulate …

Nearly all human complex traits and disease phenotypes exhibit some degree of sex differences,
including differences in prevalence, age of onset, severity or disease progression. Until …

Decreased zinc levels are a hallmark of prostate cancer tumors as zinc uniquely concentrates
in healthy prostate tissue. Increased dietary zinc correlates with decreased risk of …

Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes
may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are …

Background The origin of sex differences in prevalence and presentation of neuropsychiatric
and behavioral traits is largely unknown. Given established genetic contributions and …

Obsessive–compulsive disorder (OCD) is a highly heritable complex phenotype that
demonstrates sex differences in age of onset and clinical presentation, suggesting a possible sex …

Structural brain changes along the lineage leading to modern Homo sapiens contributed to
our distinctive cognitive and social abilities. However, the evolutionarily relevant molecular …

Sterol Response Element Binding Protein 2 (SREBP2) transcription factor is a master
regulator of cholesterol homeostasis. Treatment with statins, inhibitors of cholesterol synthesis, …

Pyrrolo [2, 1-b][1, 3] benzothiazoles are an important class of fused sulfur and nitrogen-containing
heterocycles intensively studied in medicinal chemistry and pharmacology. In the …