Acid-sensing ion channels (ASICs) are of the most sensitive molecular sensors of extracellular
pH change in mammals. Six isoforms of these channels are widely represented in …

Discovery of proteins expressed in the central nervous system sharing the three-finger
structure with snake α-neurotoxins provoked much interest to their role in brain functions. …

SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons
and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation skin …

Calorie-restricted (CR) diet has multiple beneficial effects on brain function. Here we report
morphological and functional changes in hippocampal astrocytes in 3-months-old mice …

The choice of a suitable detergent-based membrane mimetic is of crucial importance for
high-resolution NMR studies of membrane proteins. The present report describes a new …

Aim A high‐fat diet (HFD) is generally considered to negatively influence the body, the brain,
and cognition. Nonetheless, fat and fatty acids are essential for nourishing and constructing …

How aging affects cells of the human brain active milieu remains largely unknown. Here, we
analyze astrocytes and neurons in the neocortical tissue of younger (22–50 years) and …

Human LYNX1, belonging to the Ly6/neurotoxin family of three-finger proteins, is membrane-tethered
with a glycosylphosphatidylinositol anchor and modulates the activity of nicotinic …

The structure and dynamics of the isolated voltage-sensing domain (VSD) of the archaeal
potassium channel KvAP was studied by high-resolution NMR. The almost complete …

Weak toxin from Naja kaouthia (WTX) belongs to the group of nonconventional "three-finger"
snake neurotoxins. It irreversibly inhibits nicotinic acetylcholine receptors and allosterically …