The critical role of the ubiquitin-26S proteasome system in regulation of protein
homeostasis in eukaryotes is well established. In contrast, the impact of the ubiquitin-independent …

Hypoxia stimulates pulmonary artery smooth muscle cell (PASMC) proliferation. Recent
studies have implicated an important role for microRNAs (miRNAs) in hypoxia-mediated …

Cholesterol is a critical component of cellular membranes, regulating assembly and function
of membrane-based protein/lipid complexes. Many RNA viruses, including enteroviruses, …

All positive strand (+RNA) viruses of eukaryotes replicate their genomes in association with
membranes. The mechanisms of membrane remodeling in infected cells represent attractive …

Translation initiation of the picornavirus genome is regulated by an internal ribosome entry
site (IRES). The IRES of a neurovirulent picornavirus, the GDVII strain of Theiler's murine …

The nucleotide sequence of crossover sites in the genome of four intertypic (type 3/type 1)
poliovirus recombinants has been determined. The approximate boundaries of the crossover …

Rapid development of complex membranous replication structures is a hallmark of picornavirus
infections. However, neither the mechanisms underlying such dramatic reorganization of …

The group of enteroviruses contains many important pathogens for humans, including poliovirus,
coxsackievirus, rhinovirus, as well as newly emerging global health threats such as EV-…

Few drugs targeting picornaviruses are available, making the discovery of antivirals a high
priority. Here, we identified and characterized three compounds from a library of kinase …

The cellular protein GBF1, an activator of Arf GTPases (ArfGEF: Arf guanine nucleotide
exchange factor), is recruited to the replication organelles of enteroviruses through interaction …