Naïve and primed pluripotent states retain distinct molecular properties, yet limited knowledge
exists on how their state transitions are regulated. Here, we identify Mettl3, an N 6 -…

Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can
be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous …

Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent
stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc (…

Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. However,
the cellular origin of neuroblastoma has yet to be defined. Here we studied the single-cell …

The emergence and diversification of cell types is a leading factor in animal evolution. So far,
systematic characterization of the gene regulatory programs associated with cell type …

A hallmark of metazoan evolution is the emergence of genomic mechanisms that implement
cell-type-specific functions. However, the evolution of metazoan cell types and their …

scRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique
cell that can never be resampled, and robust analysis must separate the sampling effect …

Stable maintenance of gene regulatory programs is essential for normal function in
multicellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are …

Somatic cells can be transdifferentiated to other cell types without passing through a
pluripotent state by ectopic expression of appropriate transcription factors 1 , 2 . Recent reports …

Mouse embryonic development is a canonical model system for studying mammalian cell
fate acquisition. Recently, single-cell atlases comprehensively charted embryonic …