User profiles for Eleanor Sanderson

Eleanor Sanderson

University of Bristol
Verified email at bristol.ac.uk
Cited by 5442

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings

E Sanderson, G Davey Smith… - International journal …, 2019 - academic.oup.com
Background Mendelian randomization (MR) is a powerful tool in epidemiology that can be
used to estimate the causal effect of an exposure on an outcome in the presence of …

[HTML][HTML] A weak instrument F-test in linear IV models with multiple endogenous variables

E Sanderson, F Windmeijer - Journal of econometrics, 2016 - Elsevier
We consider testing for weak instruments in a model with multiple endogenous variables.
Unlike Stock and Yogo (2005), who considered a weak instruments problem where the rank of …

Testing and correcting for weak and pleiotropic instruments in two‐sample multivariable Mendelian randomization

E Sanderson, W Spiller, J Bowden - Statistics in medicine, 2021 - Wiley Online Library
Multivariable Mendelian randomization (MVMR) is a form of instrumental variable analysis
which estimates the direct effect of multiple exposures on an outcome using genetic variants …

[HTML][HTML] Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: a multivariable Mendelian …

TG Richardson, E Sanderson, TM Palmer… - PLoS …, 2020 - journals.plos.org
Background Circulating lipoprotein lipids cause coronary heart disease (CHD). However,
the precise way in which one or more lipoprotein lipid-related entities account for this …

Mendelian randomization

E Sanderson, MM Glymour, MV Holmes… - Nature Reviews …, 2022 - nature.com
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes. The …

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study

TG Richardson, E Sanderson, B Elsworth, K Tilling… - Bmj, 2020 - bmj.com
Objective To evaluate whether body size in early life has an independent effect on risk of
disease in later life or whether its influence is mediated by body size in adulthood. Design Two …

Multivariable Mendelian randomization and mediation

E Sanderson - Cold Spring Harbor perspectives …, 2021 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is the use of genetic variants associated with an exposure to
estimate the causal effect of that exposure on an outcome. Mediation analysis is the method …

[HTML][HTML] Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

B Brumpton, E Sanderson, K Heilbron… - Nature …, 2020 - nature.com
Estimates from Mendelian randomization studies of unrelated individuals can be biased
due to uncontrolled confounding from familial effects. Here we describe methods for within-…

[HTML][HTML] Mendelian randomisation for mediation analysis: current methods and challenges for implementation

AR Carter, E Sanderson, G Hammerton… - European journal of …, 2021 - Springer
Mediation analysis seeks to explain the pathway(s) through which an exposure affects an
outcome. Traditional, non-instrumental variable methods for mediation analysis experience a …

A cross-platform approach identifies genetic regulators of human metabolism and health

…, RA Scott, S Burgess, V Zuber, E Sanderson… - Nature Genetics, 2021 - nature.com
In cross-platform analyses of 174 metabolites, we identify 499 associations (P < 4.9 × 10 −10
) characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and …