Thioester-containing proteins and insect immunity

S Blandin, EA Levashina - Molecular immunology, 2004 - Elsevier
Here, we discuss the role of thioester-containing proteins in innate immune responses of
insects. TEPs are represented by multi-member families both in the fruitfly, Drosophila …

[HTML][HTML] Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene

…, T Köcher, M Wilm, FC Kafatos, EA Levashina - EMBO …, 2002 - embopress.org
Anopheles gambiae, the major vector of human malaria parasite, is an important insect
model to study vector–parasite interactions. Here, we developed a simple in vivo double-…

[HTML][HTML] Antimalarial responses in Anopheles gambiae: from a complement-like protein to a complement-like pathway

SA Blandin, E Marois, EA Levashina - Cell host & microbe, 2008 - cell.com
Malaria transmission between humans depends on the ability of Anopheles mosquitoes to
support Plasmodium development. New perspectives in vector control are emerging from …

Immunity-Related Genes and Gene Families in Anopheles gambiae

…, JA Hoffmann, SM Kanzok, I Letunic, EA Levashina… - Science, 2002 - science.org
We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate
immunity and have detected marked diversification relative to Drosophila melanogaster. …

Innate immune defense against malaria infection in the mosquito

G Dimopoulos, HM Müller, EA Levashina… - Current opinion in …, 2001 - Elsevier
Anopheles gambiae, the most important vector of malaria, employs its innate immune system
in the fight against Plasmodium. This can affect the propagative capacity of Plasmodium in …

[HTML][HTML] Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae

…, CJ Janse, AP Waters, FC Kafatos, EA Levashina - Cell, 2004 - cell.com
Anopheles mosquitoes are major vectors of human malaria in Africa. Large variation exists
in the ability of mosquitoes to serve as vectors and to transmit malaria parasites, but the …

[HTML][HTML] Midgut Microbiota of the Malaria Mosquito Vector Anopheles gambiae and Interactions with Plasmodium falciparum Infection

…, PH Awono-Ambene, EA Levashina… - PLoS …, 2012 - journals.plos.org
The susceptibility of Anopheles mosquitoes to Plasmodium infections relies on complex
interactions between the insect vector and the malaria parasite. A number of studies have …

Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes

…, H Jiang, MR Kanost, AC Koutsos, EA Levashina… - science, 2007 - science.org
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public
health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes …

[HTML][HTML] Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae

EA Levashina, LF Moita, S Blandin, G Vriend… - Cell, 2001 - cell.com
We characterize a novel hemocyte-specific acute phase glycoprotein from the malaria vector,
Anopheles gambiae. It shows substantial structural and functional similarities, including the …

Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila

EA Levashina, E Langley, C Green, D Gubb… - Science, 1999 - science.org
The antifungal defense of Drosophila is controlled by the spaetzle/Toll/cactus gene cassette.
Here, a loss-of-function mutation in the gene encoding a blood serine protease inhibitor, …