A high-throughput screening campaign was conducted to interrogate a 380,000+ small-molecule
library for novel D2 dopamine receptor modulators using a calcium mobilization assay. …

Efficient translation of human induced pluripotent stem cells (hiPSCs) requires scalable cell
manufacturing strategies for optimal self-renewal and functional differentiation. Traditional …

Human gliogenesis remains poorly understood, and derivation of astrocytes from human
pluripotent stem cells (hPSCs) is inefficient and cumbersome. Here, we report controlled glial …

Infection with human cytomegalovirus (HCMV) is a threat for pregnant women and
immunocompromised hosts. Although limited drugs are available, development of new agents …

Brain injury and inflammation induces a local release of extracellular vesicles (EVs) from
astrocytes carrying proteins, RNAs, and microRNAs into the circulation. When these vesicles …

… Elena Barnaeva; Elena Barnaeva … Trinidad-Pineiro, Lesley Mathews Griner, Rebecca
King, Elena Barnaeva, Xin Hu, Noel T. Southall, Marc Ferrer, Daniel L. Gustafson, Daniel P. …

Eya proteins are essential co-activators of the Six family of transcription factors and contain
a unique tyrosine phosphatase domain belonging to the haloacid dehalogenase family of …

Resolution of acute inflammation is governed, in part, by specialized pro-resolving
mediators, including lipoxins, resolvins, protectins, and maresins. Among them, resolvin D1 (RvD1) …

Fibrosis is an underlying cause of cirrhosis and hepatic failure resulting in end stage liver
disease with limited pharmacological options. The beneficial effects of relaxin peptide …

The D2 dopamine receptor (D2 DAR) is one of the most validated drug targets for
neuropsychiatric and endocrine disorders. However, clinically approved drugs targeting D2 DAR …