In the present work, we studied the differentiation capacity of mouse embryonic stem cells (mESCs)
and mouse embryonic fibroblasts (MEFs) to differentiate into osteoblast-like cells in a …

We have previously provided the first genetic evidence that angiotensin converting enzyme
2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS-…

The utility of induced pluripotent stem (iPS) cells for investigating the molecular logic of
pluripotency and for eventual clinical application is limited by the low efficiency of current …

The generation of induced pluripotent stem (iPS) cells has enabled the derivation of patient-specific
pluripotent cells and provided valuable experimental platforms to model human …

In recent years considerable progress has been made in the development of faithful procedures
for the differentiation of human pluripotent stem cells (hPSCs). An important step in this …

Discarded human donor organs have been shown to provide decellularized extracellular
matrix (dECM) scaffolds suitable for organ engineering. The quest for appropriate cell sources …

Fundamental biological processes are carried out by curved epithelial sheets that enclose a
pressurized lumen. How these sheets develop and withstand three-dimensional …

Gamete failure-derived infertility affects millions of people worldwide; for many patients,
gamete donation by unrelated donors is the only available treatment. Embryonic stem cells (…

The generation of organoids is one of the biggest scientific advances in regenerative medicine.
Here, by lengthening the time that human pluripotent stem cells (hPSCs) were exposed …

It is not well understood why diabetic individuals are more prone to develop severe COVID-19.
To this, we here established a human kidney organoid model promoting early hallmarks …