Background and aims: Inflammatory bowel diseases (IBDs) are associated with uncontrolled
innate and adaptive immunity against normal constituents, including commensal bacteria …

BACKGROUND & AIMS: Crohn's disease is a chronic disease characterized by severe T-helper
(Th)1 cell–driven inflammation of the colon partially caused by a loss of immune …

Objective Rheumatoid arthritis (RA) is a chronic autoimmune disease caused by loss of
immunologic self tolerance and characterized by chronic joint inflammation. Adult mesenchymal …

Objectives: Adult mesenchymal stem cells were recently found to suppress effector T cell
and inflammatory responses and have emerged as attractive therapeutic candidates for …

Background & Aims: Ghrelin is a novel growth hormone-releasing peptide with potential
endogenous anti-inflammatory activities ameliorating some pathologic inflammatory conditions. …

The induction of antigen-specific tolerance is essential to maintain immune homeostasis,
control autoreactive T cells, prevent the onset of autoimmune diseases and achieve tolerance …

Objective To investigate the effect of adipose-derived mesenchymal stromal cells (ASCs) on
the activation state of macrophages (MΦ) in vitro, and the potential therapeutic effect of …

The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and
maintenance of immune tolerance. In addition to their classical role as sentinels of the …

Rationale: Previous studies suggest an important immunoregulatory role of vasoactive intestinal
peptide (VIP) in experimental models of chronic noninfectious inflammation. Sarcoidosis …

Induction of antigen-specific tolerance is critical for autoimmunity prevention and immune
tolerance maintenance. In addition to their classical role as sentinels of the immune response, …