Scientific advances have not been enough to combat the growing resistance to antimicrobial
medicines. Antimicrobial peptides (AMPs) are effector molecules of the innate immune …

Background Antimicrobial peptides, natural or synthetic, appear as promising molecules for
antimicrobial therapy because of their both broad antimicrobial activity and mechanism of …

CD4 + T cells are key components of the immune response during lung infections and can
mediate protection against tuberculosis (TB) or influenza. However, CD4 + T cells can also …

The chemical study of roots from Azadirachta indica A. Juss., Meliaceae, led to the isolation
of two new terpenoids, limonoid morenolide and diterpene 17-hydroxy-sandaracopimar-8,15-…

Six previously undescribed intact limonoids together with four known compounds were
isolated from the seeds of Trichilia lepidota subsp. schumanniana (Harms) TDPenn. Their …

A phytochemical study of leaves and twigs of Psychotria nuda resulted in 19 compounds,
including five indole alkaloids, N,N,N-trimethyltryptamine, lyaloside, strictosamide, strictosidine, …

Microbial resistance to available drugs is a growing health threat imposing the need for the
development of new drugs. The scaffold of plant defensins, including their γ-cores, are …

Antifungal resistance poses a significant challenge to disease management, necessitating
the development of novel drugs. Antimicrobial peptides offer potential solutions. This study …

Piper multinodum C. DC. belongs to the Piperaceae family, and is known as “Jaborandi-manso”.
This species has no reported botanical, chemical, pharmacological and/or toxicological …

Tuberculosis remains a major health problem worldwide. Drug-resistant and hypervirulent
Mycobacterium tuberculosis (Mtb) strains can lead to a hyperinflammatory response and …