Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating
evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT …

Objectives: To compare quantitative EEG signal and test-retest reliability of medical grade and
consumer EEG systems. Methods: Resting state EEG was acquired by two medical grade (…

Importance Understanding the natural history of familial amyotrophic lateral sclerosis (ALS)
caused by SOD1 mutations (ALS SOD1 ) will provide key information for optimising clinical …

Triggers of innate immune signaling in the CNS of patients with amyotrophic lateral sclerosis
and frontotemporal degeneration (ALS/FTD) remain elusive. We report the presence of …

The main objective of this study was to utilize high field (7T) in vivo proton magnetic
resonance imaging to increase the ability to detect metabolite changes in people with ALS, …

In Alzheimer’s disease, the spread of aberrantly phosphorylated tau is an important criterion
in the Braak staging of disease severity and correlates with disease symptomatology. Here, …

AMPA receptors (AMPARs) are ionotropic glutamate receptors that play a major role in
excitatory neurotransmission. AMPARs are located at both presynaptic and postsynaptic plasma …

Sensitive cognitive assessments accurately detect and track cognitive decline in Alzheimer’s
disease. The Cogstate battery was used to measure cognitive change in cognitively normal …

Amyotrophic Lateral Sclerosis-Frontotemporal Dementia (ALS-FTD) may present typical
behavioral variant FTD symptoms. This study aims to determine whether profile and severity of …

A 6-months rodent toxicology and pharmacokinetic (PK) study was performed to provide
supportive safety data for long-term use of intravenous ceftriaxone in a clinical trial in patients …