Hypoxia is an important factor that elicits numerous physiological and pathological responses.
One of the major gene expression programs triggered by hypoxia is mediated through …

cDNA microarray hybridization was used in an attempt to identify novel genes participating
in cellular responses to prolonged hypoxia. One of the identified novel genes, designated …

CRISPR–Cas genome editing creates targeted DNA double-strand breaks (DSBs) that are
processed by cellular repair pathways, including the incorporation of exogenous DNA via …

Clustered, regularly interspaced, short palindromic repeat (CRISPR)–CRISPR-associated 9
(Cas9) genome editing is revolutionizing fundamental research and has great potential for …

In parallel with evolutionary developments, the Hsp90 molecular chaperone system shifted
from a simple prokaryotic factor into an expansive network that includes a variety of …

Heat shock factor 1 (HSF1) is critical for defending cells from both acute and chronic stresses.
In aging cells, the DNA binding activity of HSF1 deteriorates correlating with the onset of …

Missense mutations that disrupt the RING domain of the tumor suppressor gene BRCA1
lead to increased risk of breast and ovarian cancer. The BRCA1 RING domain is a ubiquitin …

Cellular processes function through multistep pathways that are reliant on the controlled
association and disassociation of sequential protein complexes. While dynamic action is critical …

DNA damage activates a robust transcriptional stress response, but much less is known
about how DNA damage impacts translation. The advent of genome editing with Cas9 has …

We have previously demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) activates
human T-cell leukemia virus type-I long terminal repeat (LTR) in Jurkat cells by a protein …