[HTML][HTML] Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
…, Y Chai, JGSCS Gonçalves, EM Manolika… - Nature cell …, 2023 - nature.com
Chromatin is dynamically reorganized when DNA replication forks are challenged. However,
the process of epigenetic reorganization and its implication for fork stability is poorly …
the process of epigenetic reorganization and its implication for fork stability is poorly …
[HTML][HTML] RIF1 promotes replication fork protection and efficient restart to maintain genome stability
C Mukherjee, V Tripathi, EM Manolika… - Nature …, 2019 - nature.com
Homologous recombination (HR) and Fanconi Anemia (FA) pathway proteins in addition to
their DNA repair functions, limit nuclease-mediated processing of stalled replication forks. …
their DNA repair functions, limit nuclease-mediated processing of stalled replication forks. …
[HTML][HTML] Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51
AM Heijink, C Stok, D Porubsky, EM Manolika… - Nature …, 2022 - nature.com
Sister chromatid exchanges (SCEs) are products of joint DNA molecule resolution, and are
considered to form through homologous recombination (HR). Indeed, SCE induction upon …
considered to form through homologous recombination (HR). Indeed, SCE induction upon …
[PDF][PDF] Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
…, V Tripathi, I van der Heijden, K Cong, EM Manolika… - Molecular cell, 2021 - cell.com
Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have entered the clinic for the
treatment of homologous recombination (HR)-deficient cancers. Despite the success of this …
treatment of homologous recombination (HR)-deficient cancers. Despite the success of this …
SMARCAD1-mediated active replication fork stability maintains genome integrity
…, V Gaggioli, M Paes Dias, Y Zhu, EM Manolika… - Science …, 2021 - science.org
The stalled fork protection pathway mediated by breast cancer 1/2 (BRCA1/2) proteins is
critical for replication fork stability. However, it is unclear whether additional mechanisms are …
critical for replication fork stability. However, it is unclear whether additional mechanisms are …
Loss of nuclear DNA ligase III can revert PARP inhibitor resistance in BRCA1-deficient cells by increasing DNA replication stress
…, V Tripathi, I van der Heijden, K Cong, EM Manolika… - bioRxiv, 2021 - biorxiv.org
Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have entered the clinic for the
treatment of homologous recombination (HR)-deficient cancers. Despite the success of this …
treatment of homologous recombination (HR)-deficient cancers. Despite the success of this …
Detection Of Replication Forks In Em Images Using Faster R-Cnn
W Zhao, EM Manolika, AR Chaudhuri… - 2021 IEEE 18th …, 2021 - ieeexplore.ieee.org
Currently, one of the most effective techniques to study the mechanisms of DNA replication
is using the electron microscopy. Typical imaging experiments result in terabytes of image …
is using the electron microscopy. Typical imaging experiments result in terabytes of image …
Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1-Deficient Cells by Increasing DNA Replication Stress
…, V Tripathi, I van der Heijden, K Cong, EM Manolika… - papers.ssrn.com
Inhibitors of poly (ADP-ribose)(PAR) polymerase (PARPi) have entered the clinic for the
treatment of homologous recombination (HR)-deficient cancers. Despite the success of this …
treatment of homologous recombination (HR)-deficient cancers. Despite the success of this …
Interplay of SMARCAD1 and BRCA1 at Replication Forks to Maintain Genome Integrity
…, V Gaggioli, MP Dias, Y Zhu, EM Manolika… - papers.ssrn.com
Chemotherapeutic regimens that poison DNA replication are used for the treatment of
homologous recombination (HR)-deficient cancers. We have discovered a novel mechanism by …
homologous recombination (HR)-deficient cancers. We have discovered a novel mechanism by …
[HTML][HTML] Recapitulating cholangiopathy-associated necroptotic cell death in vitro using human cholangiocyte organoids
S Shi, MMA Verstegen, HP Roest, AI Ardisasmita… - Cellular and Molecular …, 2022 - Elsevier
… The authors thank Ivo Schurink for his kind help with the collection of clinical data; Remco
de Louw and Eleni Maria Manolika for their outstanding technical support; and Michael …
de Louw and Eleni Maria Manolika for their outstanding technical support; and Michael …