Sepsis is caused by systemic infection and is a major health concern as it is the primary
cause of death from infection. It is the leading cause of mortality worldwide and there are no …

KRIT1 loss-of-function mutations underlie the pathogenesis of Cerebral Cavernous Malformation
(CCM), a major vascular disease affecting the central nervous system (CNS). However, …

Objective: The aim of this study was to investigate (a) the potential of the Bruton's tyrosine
kinase (BTK) inhibitors acalabrutinib and fenebrutinib to reduce multiple organ dysfunction …

Diets with an elevated content of fat, sucrose, or fructose are recognized models of diet-induced
metabolic alterations, since they induce metabolic derangements, oxidative stress, and …

Nonalcoholic fatty liver disease (NAFLD) is the leading liver chronic disease featuring hepatic
steatosis. Mitochondrial β-oxidation participates in the derangement of lipid metabolism at …

Inducible T cell co-stimulator (ICOS), an immune checkpoint protein expressed on activated
T cells and its unique ligand, ICOSL, which is expressed on antigen-presenting cells and non…

Objective: The aim of this study was to investigate (a) the effects of the Janus kinase (JAK)/signal
transducer and activator of transcription (STAT) pathway inhibitor (baricitinib) on the …

Hodgkin lymphoma (HL) is today one of the most curable pediatric cancers. Despite survival
rates now exceeding 90%, survivors of pediatric HL are still at higher risk to develop late …

Advanced glycation end products (AGEs) exert a key pathogenic role in the development of
obesity and insulin resistance. Thanks to its abundance in bioactive compounds, the …

Scope Diets rich in fat and sugars evoke chronic low‐grade inflammation, leading to
metabolic derangements. This study investigates the impact of fructose and galactose, two …