[HTML][HTML] Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells
MJ Harriff, E Karamooz, A Burr, WF Grant… - PLoS …, 2016 - journals.plos.org
Mucosal-Associated Invariant T (MAIT) cells, present in high frequency in airway and other
mucosal tissues, have Th1 effector capacity positioning them to play a critical role in the early …
mucosal tissues, have Th1 effector capacity positioning them to play a critical role in the early …
MAIT cells and microbial immunity
EW Meermeier, MJ Harriff, E Karamooz… - Immunology and cell …, 2018 - Wiley Online Library
Mucosal‐associated invariant T ( MAIT ) cells, the most abundant T‐cell subset in humans,
are increasingly being recognized for their importance in microbial immunity. MAIT cells …
are increasingly being recognized for their importance in microbial immunity. MAIT cells …
[HTML][HTML] Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism
MA Schumacher, E Karamooz, A Zíková, L Trantírek… - Cell, 2006 - cell.com
The mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that
functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker …
functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker …
[HTML][HTML] Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive
…, RL Modlin, G Swarbrick, E Karamooz… - Communications …, 2022 - nature.com
Mucosal-associated Invariant T (MAIT) cells are an innate-like T cell subset that recognize a
broad array of microbial pathogens, including respiratory pathogens. Here we investigate …
broad array of microbial pathogens, including respiratory pathogens. Here we investigate …
MR1-dependent antigen presentation
E Karamooz, MJ Harriff, DM Lewinsohn - Seminars in cell & developmental …, 2018 - Elsevier
MR1 is a non-classical class I molecule that is highly conserved among mammals. Though
discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells …
discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells …
[HTML][HTML] MR1 recycling and blockade of endosomal trafficking reveal distinguishable antigen presentation pathways between Mycobacterium tuberculosis infection …
E Karamooz, MJ Harriff, GA Narayanan, A Worley… - Scientific Reports, 2019 - nature.com
The MHC-Ib molecule MR1 presents microbial metabolites to MR1-restricted T cells (MR1Ts).
Given the ubiquitous expression of MR1 and the high prevalence of human MR1Ts, it is …
Given the ubiquitous expression of MR1 and the high prevalence of human MR1Ts, it is …
[HTML][HTML] Covering all the bases: Complementary MR1 antigen presentation pathways sample diverse antigens and intracellular compartments
C Kulicke, E Karamooz, D Lewinsohn… - Frontiers in …, 2020 - frontiersin.org
The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related
protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells. …
protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells. …
[HTML][HTML] Rab6 regulates recycling and retrograde trafficking of MR1 molecules
ME Huber, R Kurapova, CM Heisler, E Karamooz… - Scientific Reports, 2020 - nature.com
Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset important in the
early response to bacterial and viral lung pathogens. MAIT cells recognize bacterial small …
early response to bacterial and viral lung pathogens. MAIT cells recognize bacterial small …
[HTML][HTML] Alternative splicing of MR1 regulates antigen presentation to MAIT cells
…, J Tran, AH Worley, EW Meermeier, E Karamooz… - Scientific Reports, 2020 - nature.com
Mucosal Associated Invariant T (MAIT) cells can sense intracellular infection by a broad array
of pathogens. These cells are activated upon encountering microbial antigen(s) displayed …
of pathogens. These cells are activated upon encountering microbial antigen(s) displayed …
[HTML][HTML] Homegrown ultraviolet germicidal irradiation for hospital-based N95 decontamination during the COVID-19 pandemic
E Schnell, MJ Harriff, JE Yates, E Karamooz… - medRxiv, 2020 - ncbi.nlm.nih.gov
Coronavirus disease (COVID-19), the disease caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, is responsible for the 2020 global pandemic and …
syndrome coronavirus 2 (SARS-CoV-2) virus, is responsible for the 2020 global pandemic and …