Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive …

Abstract Models of cognitive function typically focus on the cerebral cortex and hence overlook
functional links to subcortical structures. This view does not consider the role of the highly-…

The neurobiological mechanisms of arousal and anesthesia remain poorly understood.
Recent evidence highlights the key role of interactions between the cerebral cortex and the …

Understanding the neurobiological mechanisms underlying consciousness remains a significant
challenge. Recent evidence suggests that the coupling between distal–apical and basal…

Neural dynamics are shaped and constrained by the projections of a small nucleus in the
pons: the noradrenergic locus coeruleus (LC). Much like a bow to the brain's violin, activity in …

The human brain displays a rich repertoire of states that emerge from the microscopic
interactions of cortical and subcortical neurons. Difficulties inherent within large-scale …

Cognitive activity emerges from large-scale neuronal dynamics that are constrained to a low-dimensional
manifold. How this low-dimensional manifold scales with cognitive complexity, …

Recent neuroimaging experiments have defined low-dimensional gradients of functional
connectivity in the cerebral cortex that subserve a spectrum of capacities that span from …

The biological mechanisms that allow the brain to balance flexibility and integration remain
poorly understood. A potential solution may lie in a unique aspect of neurobiology, which is …

Complex cognitive abilities are thought to arise from the ability of the brain to adaptively
reconfigure its internal network structure as a function of task demands. Recent work has …