Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand
breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus …
breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus …
[HTML][HTML] BRCA2 controls DNA: RNA hybrid level at DSBs by mediating RNase H2 recruitment
…, AR Venkitaraman, P Cejka, E Rothenberg… - Nature …, 2018 - nature.com
DNA double-strand breaks (DSBs) are toxic DNA lesions, which, if not properly repaired,
may lead to genomic instability, cell death and senescence. Damage-induced long non-coding …
may lead to genomic instability, cell death and senescence. Damage-induced long non-coding …
Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair
…, DA Ramsden, E Rothenberg - Proceedings of the …, 2015 - National Acad Sciences
Nonhomologous end-joining (NHEJ) is a major repair pathway for DNA double-strand breaks
(DSBs), involving synapsis and ligation of the broken strands. We describe the use of in …
(DSBs), involving synapsis and ligation of the broken strands. We describe the use of in …
Selective growth of metal tips onto semiconductor quantum rods and tetrapods
We show the anisotropic selective growth of gold tips onto semiconductor (cadmium selenide)
nanorods and tetrapods by a simple reaction. The size of the gold tips can be controlled …
nanorods and tetrapods by a simple reaction. The size of the gold tips can be controlled …
The molecular basis and disease relevance of non-homologous DNA end joining
B Zhao, E Rothenberg, DA Ramsden… - … Reviews Molecular Cell …, 2020 - nature.com
Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any
type of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …
type of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …
[PDF][PDF] CDK7 inhibition potentiates genome instability triggering anti-tumor immunity in small cell lung cancer
…, A Kersbergen, AJ Aguirre, GC Yuan, E Rothenberg… - Cancer cell, 2020 - cell.com
Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene transcription.
However, little is known about its impact on genomic instability and cancer immunity. …
However, little is known about its impact on genomic instability and cancer immunity. …
[PDF][PDF] Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
…, JJ Turchi, N Johnson, J Jonkers, E Rothenberg… - Molecular cell, 2021 - cell.com
Mutations in BRCA1 or BRCA2 (BRCA) is synthetic lethal with poly(ADP-ribose) polymerase
inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded breaks (DSBs) …
inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded breaks (DSBs) …
Synthesis and size-dependent properties of zinc-blende semiconductor quantum rods
Dimensionality and size are two factors that govern the properties of semiconductor
nanostructures 1 , 2 . In nanocrystals, dimensionality is manifested by the control of shape, which …
nanostructures 1 , 2 . In nanocrystals, dimensionality is manifested by the control of shape, which …
KRAS4A directly regulates hexokinase 1
…, J Shi, SL Mendoza, MJ Morten, E Rothenberg… - Nature, 2019 - nature.com
The most frequently mutated oncogene in cancer is KRAS, which uses alternative fourth
exons to generate two gene products (KRAS4A and KRAS4B) that differ only in their C-terminal …
exons to generate two gene products (KRAS4A and KRAS4B) that differ only in their C-terminal …
[HTML][HTML] Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
Guanine-rich DNA sequences occur throughout the human genome and can transiently
form G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic …
form G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic …